Fw: MESOMARK kit detects C-ERC/mesothelin, but not SMRP with C-terminus.

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From: HubMed - mesothelioma <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Tuesday, March 11, 2008 10:08:51 PM
Subject: MESOMARK kit detects C-ERC/mesothelin, but not SMRP with C-terminus.

[1]Biochem Biophys Res Commun. 2008 Mar 4;
Segawa T, Hagiwara Y, Ishikawa K, Aoki N, Maeda M, Shiomi K, Hino O

ERC/mesothelin is expressed on the normal mesothelium and some cancers such as mesothelioma or ovarian carcinoma. A splicing isoform of ERC/mesothelin (known as SMRP), which has an 82-bp insertion and codes for a C-terminus with a hydrophilic, presumably soluble, tail instead of a GPI-anchoring signal, has been reported as a useful marker for the diagnosis of mesothelioma. However, the existence of SMRP has not yet been demonstrated in the serum of mesothelioma patients. To elucidate the existence of SMRP, we have established a new enzyme-linked immunosorbent assay (ELISA) system for SMRP. The ELISA study revealed that N- and C-ERC/mesothelin were detected in sera from mesothelioma patients, but not SMRP, even in these samples. This result showed that the SMRP detected with MESOMARK kit should be lack of soluble C-terminus and indistinguishable from C-ERC/mesothelin. Further study might be necessary to demonstrate the relationship between SMRP and mesothelin.



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Fw: A conditional mouse model for malignant mesothelioma.

----- Forwarded Message ----
From: HubMed - mesothelioma <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Tuesday, March 11, 2008 10:08:51 PM
Subject: A conditional mouse model for malignant mesothelioma.

[1]Cancer Cell. 2008 Mar; 13(3): 261-71
Jongsma J, van Montfort E, Vooijs M, Zevenhoven J, Krimpenfort P, van der Valk M, van de Vijver M, Berns A

Malignant mesothelioma is a devastating disease that has been associated with loss of Neurofibromatosis type 2 (NF2) and genetic lesions affecting RB and P53 pathways. We introduced similar lesions in the mesothelial lining of the thoracic cavity of mice. Mesothelioma developed at high incidence in Nf2;Ink4a/Arf and Nf2;p53 conditional knockout mice with median survival times of approximately 30 and 20 weeks, respectively. Murine mesothelioma closely mimicked human malignant mesothelioma. Conditional Nf2;Ink4a/Arf mice showed increased pleural invasion compared to conditional Nf2;p53 mice. Interestingly, upon Ink4a loss in the latter mice median survival was significantly reduced and all tumors were highly invasive, suggesting that Ink4a loss substantially contributes to the poor clinical outcome of malignant mesothelioma.



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Fwd: $3 Billion Asbestos Deal Reached by W.R.Grace Company to Pay Asbestos Victims (PR Newswire via Yahoo! Finance)

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From: Yahoo! News Search Results for asbestos cancer <rssfwd@rssfwd.com>
Date: Mon, Apr 7, 2008 at 12:04 PM
Subject: $3 Billion Asbestos Deal Reached by W.R.Grace Company to Pay Asbestos Victims (PR Newswire via Yahoo! Finance)
To: mesothelioma77@gmail.com


Principals announced today a $3 billion dollar agreement to resolve current and future asbestos claims with chemical manufacturer W.R.Grace & Co. and related entities, which will eventually allow the multinational corporation to emerge from bankruptcy with no further obligations for asbestos injury liability.

Mon, 07 Apr 2008 14:23:00 GMT

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Fwd: Grace to settle thousands of asbestos-related claims

---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Mon, Apr 7, 2008 at 12:04 PM
Subject: Grace to settle thousands of asbestos-related claims
To: mesothelioma77@gmail.com

Chemical maker W.R. Grace & Co. said this morning that it would settle thousands of asbestos-related personal injury claims spanning decades.

Mon, 07 Apr 2008 15:41:04 GMT

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Fwd: New Data On Infinity's Lead Anti-Cancer Candidates to be Presented At AACR

---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Mon, Apr 7, 2008 at 12:05 PM
Subject: New Data On Infinity's Lead Anti-Cancer Candidates to be Presented At AACR
To: mesothelioma77@gmail.com

Infinity Pharmaceuticals, Inc. , an innovative cancer drug discovery and development company, today announced that new data from several preclinical studies of the company's novel small molecule drug candidates ...

Mon, 07 Apr 2008 14:33:08 GMT

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Fwd: Curis Announces Presentation at the 235th American Chemical Society National Meeting

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From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Mon, Apr 7, 2008 at 12:05 PM
Subject: Curis Announces Presentation at the 235th American Chemical Society National Meeting
To: mesothelioma77@gmail.com

Curis, Inc. , a drug development company focused on developing proprietary targeted medicines primarily for cancer treatment, today announced that Curis scientists presented a poster entitled "Design and ...

Mon, 07 Apr 2008 13:09:38 GMT

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