---------- Forwarded message ----------
From:
HubMed - breast cancer <
rssfwd@rssfwd.com>
Date: Sat, May 3, 2008 at 11:09 PM
Subject: The Average Cumulative Risks of Breast and Ovarian Cancer for Carriers of Mutations in BRCA1 and BRCA2 Attending Genetic Counseling Units in Spain.
To:
mesothelioma77@gmail.com [1]Clin Cancer Res. 2008 May 1; 14(9): 2861-9
Milne RL, Osorio A, Cajal TR, Vega A, Llort G, de la Hoya M, Díez O, Alonso MC, Lazaro C, Blanco I, Sánchez-de-Abajo A, Caldés T, Blanco A, Graña B, Durán M, Velasco E, Chirivella I, Cardeñosa EE, Tejada MI, Beristain E, Miramar MD, Calvo MT, Martínez E, Guillén C, Salazar R, San Román C, Antoniou AC, Urioste M, Benítez J
PURPOSE: It is not clear that the published estimates of the breast and ovarian cancer penetrances of mutations in BRCA1 and BRCA2 can be used in genetic counseling in countries such as Spain, where the incidence of breast cancer in the general population is considerably lower, the prevalence of BRCA2 mutations seems to be higher, and a distinct spectrum of recurrent mutations exists for both genes. We aimed to estimate these penetrances for women attending genetic counseling units in Spain. EXPERIMENTAL DESIGN: We collected phenotype and genotype data on 155 BRCA1 and 164 BRCA2 mutation carrier families from 12 centers across the country. Average age-specific cumulative risks of breast cancer and ovarian cancer were estimated using a modified segregation analysis method. RESULTS: The estimated average cumulative risk of breast cancer to age 70 years was estimated to be 52% [95% confidence interval (95% CI), 26-69%] for BRCA1 mutation carriers and 47% (95% CI, 29-60%) for BRCA2 mutation carriers. The corresponding estimates for ovarian cancer were 22% (95% CI, 0-40%) and 18% (95% CI, 0-35%), respectively. There was some evidence (two-sided P = 0.09) that 330A>G (R71G) in BRCA1 may have lower breast cancer penetrance. CONCLUSIONS: These results are consistent with those from a recent meta-analysis of practically all previous penetrance studies, suggesting that women with BRCA1 and BRCA2 mutations attending genetic counseling services in Spain have similar risks of breast and ovarian cancer to those published for other Caucasian populations. Carriers should be fully informed of their mutation- and age-specific risks to make appropriate decisions regarding prophylactic interventions such as oophorectomy.
___
Source:
http://www.hubmed.org/display.cgi?uids=18451254--
~
Powered by [5]RssFwd, a service of [6]Blue Sky Factory, Inc
Your Finance:
Sitemap
Debts, Loans And Consolidation Tips, Guide, Strategies And Info:
Debts and Loan Consolidation
Managing Your Debts
Debt Consolidation Loan
Consolidate Debt Loans: For Better Debt Management
Consolidate Debt Loans: To Eliminate Credit Card Debts
Consolidate Debt Loans
Consolidate Debt Loans For Your School Debts
Debt Consolidation UK
Debt Consolidation UK; Secured and Unsecured Debt Consolidation Explained
Private Student Loans: A Parent's Best Choice?
College Consolidation Loans
School Consolidation Loan Guide
School Loan Consolidation
School Loan Consolidation: Your Much Needed Information
School Consolidation Loan
Enter Bankruptcy Protection
Bankruptcy Mailing List
Bankruptcy Marketing
Your Mortgage Tips, Guide, Strategies And Info
Mortgage Loans
Mortgage Refinancing
How Much Mortgage Can I Afford?
Best Mortgage Rates Refinancing
Low Mortgage Rate Refinance
Connecticut Mortgage Refinancing
Mortgage Loan Refinancing In Britain
UK Mortgage Payment Calculator
Arkansas Refinance Mortgage Rates
Home Loan Rates Berkeley Springs
Home Loan Rates WV
Mortgage Rate History
What is Subprime Mortgage?
Foreclosures Tips, Guide, Strategies and Info Sites
Foreclosures
Foreclosures Bank Owned
Mortgage Foreclosure Appraisal
Property Foreclosures
Reasons Foreclosures Occur
Avoid Foreclosure
Deed In Lieu Of Foreclosure
Regulations Preventing Foreclosure
Your Real Estate Tips, Guide, Strategies And Info:
Real Estate: Important Things to Remember
MS Beach Vacation Condos
Real Estate Marbella
Franklin TN Real Estate
Hud Homes Savannah Georgia
Margate Real Estate
Hud Approved Builders
It's All About Your Insurance
Insurance Premiums and Your DUI, DWI
The Role of Insurance
Insurance Defined
Low Car Insurance Rate Canada
Your DWI And DUI Tips, Guide And Info:
97402 Dui Classses
Austin DWI Attorney Info
Florida DWI Arrest
Austin DWI and DUI Defined
Florida Dwi Defense
Your Pet Dogs Needs, Tips, Guide, Strategies, and Info
Pet Dogs Wellness
Air Filled Dog Bed
Transport Dog Crates
Dog Transport
Air Filled Dog Bed: Your Best Friends Comfort
Unique Dog Collars
Dog Crate Training
Popular Transport Dog Crates
Puppy Colic
Pet Dogs: Breeds With Behavioral Problems?
Your Health Tips, Guide and Info
Health Wellness
Relieve Stress Anxiety Tensions
Holiday Stress
Mind Body Yoga
Mesothelioma
Mesothelioma diagnosis: What You Need To Know
Daily Recommended Relaxation
Transcendental Meditation
More Articles For You
Related Articles