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Tuesday, March 25, 2008
Fw: Advances in the molecular biology of malignant mesothelioma.
----- Forwarded Message ----
From: HubMed - mesothelioma diagnosis <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Sunday, March 9, 2008 10:12:20 AM
Subject: Advances in the molecular biology of malignant mesothelioma.
[1]Acta Med Okayama. 2008 Feb; 62(1): 1-7
Toyooka S, Kishimoto T, Date H
Malignant mesothelioma (MM) is a highly aggressive tumor with a dismal prognosis. The incidence of MM is increasing as a result of widespread exposure to asbestos. As for the molecular alterations that occur in MM, chromosome alterations including homo-deletion of the P16 and P14 genes located in the 9p21 are well known. Mutations are rare in the P53 and Ras genes, which are frequently present in epithelial solid tumors. However, mutations are frequently present in the neurofibromatosis type 2 gene. Epigenetic alterations including DNA methylation have been found in the MM, the profile of which is different from that of lung cancer, although differential diagnosis is sometimes clinically difficult. As in other malignant tumors, genes that are related to immortalization, proliferation, metastasis, angiogenesis, and anti-apoptosis are also overexpressed in MM, contributing to its malignant phenotype. It is of interest that simian virus 40 has been implicated to be one of the causative factors of MM in western countries. Although the causative role of asbestos is well-known in MM, much less information is available for MM than for other malignant tumors regarding the molecular alterations that occur in the disease. In terms of future tasks, it will be necessary to apply the knowledge that is learned about molecular alterations to clinical practice and to further elucidate the pathogenesis of MM with extensive research.
___
Source: http://www.hubmed.org/display.cgi?uids=18323865
--
~
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From: HubMed - mesothelioma diagnosis <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Sunday, March 9, 2008 10:12:20 AM
Subject: Advances in the molecular biology of malignant mesothelioma.
[1]Acta Med Okayama. 2008 Feb; 62(1): 1-7
Toyooka S, Kishimoto T, Date H
Malignant mesothelioma (MM) is a highly aggressive tumor with a dismal prognosis. The incidence of MM is increasing as a result of widespread exposure to asbestos. As for the molecular alterations that occur in MM, chromosome alterations including homo-deletion of the P16 and P14 genes located in the 9p21 are well known. Mutations are rare in the P53 and Ras genes, which are frequently present in epithelial solid tumors. However, mutations are frequently present in the neurofibromatosis type 2 gene. Epigenetic alterations including DNA methylation have been found in the MM, the profile of which is different from that of lung cancer, although differential diagnosis is sometimes clinically difficult. As in other malignant tumors, genes that are related to immortalization, proliferation, metastasis, angiogenesis, and anti-apoptosis are also overexpressed in MM, contributing to its malignant phenotype. It is of interest that simian virus 40 has been implicated to be one of the causative factors of MM in western countries. Although the causative role of asbestos is well-known in MM, much less information is available for MM than for other malignant tumors regarding the molecular alterations that occur in the disease. In terms of future tasks, it will be necessary to apply the knowledge that is learned about molecular alterations to clinical practice and to further elucidate the pathogenesis of MM with extensive research.
___
Source: http://www.hubmed.org/display.cgi?uids=18323865
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Fwd: Efficacy and safety of pemetrexed in elderly cancer patients: Results of an integrated analysis.
---------- Forwarded message ----------
From: HubMed - mesothelioma cancer <rssfwd@rssfwd.com>
Date: Tue, Mar 25, 2008 at 2:49 PM
Subject: Efficacy and safety of pemetrexed in elderly cancer patients: Results of an integrated analysis.
To: mesothelioma77@gmail.com
[1]Crit Rev Oncol Hematol. 2008 Mar 19;
Kulkarni PM, Chen R, Anand T, Monberg MJ, Obasaju CK
PURPOSE: To analyze pemetrexed in elderly patients (>/=65 years) based on data collected in three randomized, phase III registration trials. METHODS: Patients who received pemetrexed as monotherapy or in combination with another drug were included in this analysis (N=764). In all studies, pemetrexed 500mg/m(2) was administered every 21 days. Data from patients receiving pemetrexed were stratified by age +/-65 years. RESULTS: Out of the 764 patients randomized, 271 were >/=65 years of age (35.4%). Of these, 28% had non-small cell lung cancer, 41% pancreatic cancer, and 31% had malignant pleural mesothelioma that was either locally advanced or metastatic. The overall response rate of the integrated database of elderly patients was 21.4%, with complete response in three patients (1.11% in >/=65 years vs. 1.01% in
___
Source: http://www.hubmed.org/display.cgi?uids=18358737
--
~
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From: HubMed - mesothelioma cancer <rssfwd@rssfwd.com>
Date: Tue, Mar 25, 2008 at 2:49 PM
Subject: Efficacy and safety of pemetrexed in elderly cancer patients: Results of an integrated analysis.
To: mesothelioma77@gmail.com
[1]Crit Rev Oncol Hematol. 2008 Mar 19;
Kulkarni PM, Chen R, Anand T, Monberg MJ, Obasaju CK
PURPOSE: To analyze pemetrexed in elderly patients (>/=65 years) based on data collected in three randomized, phase III registration trials. METHODS: Patients who received pemetrexed as monotherapy or in combination with another drug were included in this analysis (N=764). In all studies, pemetrexed 500mg/m(2) was administered every 21 days. Data from patients receiving pemetrexed were stratified by age +/-65 years. RESULTS: Out of the 764 patients randomized, 271 were >/=65 years of age (35.4%). Of these, 28% had non-small cell lung cancer, 41% pancreatic cancer, and 31% had malignant pleural mesothelioma that was either locally advanced or metastatic. The overall response rate of the integrated database of elderly patients was 21.4%, with complete response in three patients (1.11% in >/=65 years vs. 1.01% in
___
Source: http://www.hubmed.org/display.cgi?uids=18358737
--
~
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Fwd: Metastatic breast cancer: The role of pegylated liposomal doxorubicin after conventional anthracyclines.
---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Tue, Mar 25, 2008 at 2:50 PM
Subject: Metastatic breast cancer: The role of pegylated liposomal doxorubicin after conventional anthracyclines.
To: mesothelioma77@gmail.com
[1]Cancer Treat Rev. 2008 Mar 19;
Verma S, Dent S, Chow BJ, Rayson D, Safra T
Anthracyclines demonstrate significant disease activity in breast cancer and are a key component of therapy in both early and advanced disease. It has been long recognized that these agents are associated with cumulative dose-related cardiotoxicity that often limits their utility at the time of disease recurrence. The risk of anthracycline-associated cardiotoxicity appears to be highest in women with HER2-overexpressing breast cancer previously having received an adjuvant anthracycline-trastuzumab regimen. Clinical trials have demonstrated that pegylated liposomal doxorubicin (PLD) is equally active but associated with a significantly lower risk of cardiotoxicity compared with conventional doxorubicin whether administered as monotherapy or in combination with trastuzumab. Thus, PLD can be effectively and safely substituted for conventional doxorubicin, allowing retreatment with an anthracycline in the metastatic setting. PLD has also been shown to improve time to tumor progression when used as maintenance therapy. These data, when coupled with the need to maintain efficacy and reduce cardiotoxicity in the management of metastatic breast cancer, support the use of PLD in the metastatic setting, as well as support the rationale for evaluating PLD as adjuvant therapy.
___
Source: http://www.hubmed.org/display.cgi?uids=18358614
--
~
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From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Tue, Mar 25, 2008 at 2:50 PM
Subject: Metastatic breast cancer: The role of pegylated liposomal doxorubicin after conventional anthracyclines.
To: mesothelioma77@gmail.com
[1]Cancer Treat Rev. 2008 Mar 19;
Verma S, Dent S, Chow BJ, Rayson D, Safra T
Anthracyclines demonstrate significant disease activity in breast cancer and are a key component of therapy in both early and advanced disease. It has been long recognized that these agents are associated with cumulative dose-related cardiotoxicity that often limits their utility at the time of disease recurrence. The risk of anthracycline-associated cardiotoxicity appears to be highest in women with HER2-overexpressing breast cancer previously having received an adjuvant anthracycline-trastuzumab regimen. Clinical trials have demonstrated that pegylated liposomal doxorubicin (PLD) is equally active but associated with a significantly lower risk of cardiotoxicity compared with conventional doxorubicin whether administered as monotherapy or in combination with trastuzumab. Thus, PLD can be effectively and safely substituted for conventional doxorubicin, allowing retreatment with an anthracycline in the metastatic setting. PLD has also been shown to improve time to tumor progression when used as maintenance therapy. These data, when coupled with the need to maintain efficacy and reduce cardiotoxicity in the management of metastatic breast cancer, support the use of PLD in the metastatic setting, as well as support the rationale for evaluating PLD as adjuvant therapy.
___
Source: http://www.hubmed.org/display.cgi?uids=18358614
--
~
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Fwd: Top Scoops (Scoop.co.nz)
---------- Forwarded message ----------
From: Yahoo! News Search Results for asbestos cancer <rssfwd@rssfwd.com>
Date: Tue, Mar 25, 2008 at 2:49 PM
Subject: Top Scoops (Scoop.co.nz)
To: mesothelioma77@gmail.com
Liberty is the only thing you cannot have unless you are willing to give it to others. -- William Allen White
Tue, 25 Mar 2008 04:00:43 GMT
___
Source: http://us.rd.yahoo.com/dailynews/rss/search/asbestos+cancer/SIG=11kg105f7/*http%3A//www.scoop.co.nz/stories/HL0803/S00398.htm
--
~
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From: Yahoo! News Search Results for asbestos cancer <rssfwd@rssfwd.com>
Date: Tue, Mar 25, 2008 at 2:49 PM
Subject: Top Scoops (Scoop.co.nz)
To: mesothelioma77@gmail.com
Liberty is the only thing you cannot have unless you are willing to give it to others. -- William Allen White
Tue, 25 Mar 2008 04:00:43 GMT
___
Source: http://us.rd.yahoo.com/dailynews/rss/search/asbestos+cancer/SIG=11kg105f7/*http%3A//www.scoop.co.nz/stories/HL0803/S00398.htm
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Real Estate: Important Things to Remember
Regulations Preventing Foreclosure
Insurance Premiums and Your DUI, DWI
The Role of Insurance Insurance Defined
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Fwd: Catherine Deveny Our environmental efforts sometimes seem futile when ...
---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Tue, Mar 25, 2008 at 2:49 PM
Subject: Catherine Deveny Our environmental efforts sometimes seem futile when ...
To: mesothelioma77@gmail.com
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Tue, Mar 25, 2008 at 2:49 PM
Subject: Catherine Deveny Our environmental efforts sometimes seem futile when ...
To: mesothelioma77@gmail.com
IS IT just me or does anyone else wonder why they're busting their balls to make a piss-weak contribution to saving the environment when most of the world, the Government and a fair whack of our neighbours ...
Source: http://www.theage.com.au/news/opinion/catherine-deveny/2008/03/25/1206207099540.html
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Tue, 25 Mar 2008 14:23:16 GMT
Source: http://www.theage.com.au/news/opinion/catherine-deveny/2008/03/25/1206207099540.html
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Insurance Premiums and Your DUI, DWI
The Role of Insurance Insurance Defined
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http://www.lingwellness.com/mortgagerefinancing.php
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Mesothelioma diagnosis: What You Need To Know
Fwd: Yale and Asuragen Scientists Show That a microRNA Can Reduce Lung Cancer Growth (Centre Daily Times)
---------- Forwarded message ----------
From: Yahoo! News Search Results for lung cancer <rssfwd@rssfwd.com>
Date: Tue, Mar 25, 2008 at 2:49 PM
Subject: Yale and Asuragen Scientists Show That a microRNA Can Reduce Lung Cancer Growth (Centre Daily Times)
To: mesothelioma77@gmail.com
A microRNA (miRNA) molecule known as let-7 substantially reduced cancer growth in multiple mouse models of lung cancer as reported by researchers at Yale University School of Medicine and Asuragen, Inc. in the journal Cell Cycle.
Tue, 25 Mar 2008 08:22:18 GMT
___
Source: http://us.rd.yahoo.com/dailynews/rss/search/lung+cancer/SIG=11peh5qck/*http%3A//www.centredaily.com/business/story/483474.html
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From: Yahoo! News Search Results for lung cancer <rssfwd@rssfwd.com>
Date: Tue, Mar 25, 2008 at 2:49 PM
Subject: Yale and Asuragen Scientists Show That a microRNA Can Reduce Lung Cancer Growth (Centre Daily Times)
To: mesothelioma77@gmail.com
A microRNA (miRNA) molecule known as let-7 substantially reduced cancer growth in multiple mouse models of lung cancer as reported by researchers at Yale University School of Medicine and Asuragen, Inc. in the journal Cell Cycle.
Tue, 25 Mar 2008 08:22:18 GMT
___
Source: http://us.rd.yahoo.com/dailynews/rss/search/lung+cancer/SIG=11peh5qck/*http%3A//www.centredaily.com/business/story/483474.html
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School Loan Consolidation: Your Much Needed Information
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Mortgage Loans. Mortgage Loan Refinancing In Britain
Mortgage Refinancing: The Info You Need Before You Refinance
Mortgage Loan Refinancing In Britain
Mortgage Foreclosure Appraisal
Real Estate: Important Things to Remember
Regulations Preventing Foreclosure
Insurance Premiums and Your DUI, DWI
The Role of Insurance Insurance Defined
http://www.lingwellness.com/privatestudentloans.php
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http://www.lingwellness.com/privatestudentloans.php
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