From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Tue, Sep 2, 2008 at 8:26 PM
Subject: Pleiotropic effects of selective CDK inhibitors on human normal and cancer cells.
To: mesothelioma77@gmail.com
[1]Biochem Pharmacol. 2008 Aug 12;
Węsierska-Gądek J, Hajek SB, Sarg B, Wandl S, Walzi E, Lindner H
Escape from the proper control of the cell cycle by up-regulation of cyclins or aberrant activation of cyclin-dependent kinases (CDKs) as well as by inactivation of cellular inhibitors of CDKs (CKI) leads to malignant transformation. Loss of cellular CKIs in cancers provided a rationale for development of pharmacological inhibitors of CDKs. Recently synthesized CKIs, e.g., purine derivatives such as olomoucine (OLO) and roscovitine (ROSC) are non-genotoxic and exhibit increased selectivity towards CDK2 and CDK7/9. Interestingly, both drugs induce additional effects. Recently, a new, unexpected action of OLO on normal human cells was observed. OLO strongly up-regulates CLIMP-63, a 65kD protein that mediates the anchoring of the ER to microtubules. Moreover, ROSC induces in human MCF-7 cells phosphorylation of p53 protein at Ser-46 which in turn initiates caspase-independent apoptosis. In the present contribution we raised the question whether both CKIs would be able to block cell cycle progression and to reactivate p53 protein in human HPV-positive HeLa cervix carcinoma cells. We also addressed the question whether exponentially growing cancer cells are more susceptible to the inhibitory action of CKIs than normal cells. Our results show that HeLa cells are much more sensitive to ROSC than normal fibroblasts. ROSC induces G(2) arrest and apoptosis in HeLa cells. It also reactivates and stabilizes wt p53 protein. The increase of p53 protein coincides with down-regulation of E6 oncoprotein. Thus, the biological action of substituted purines is not restricted to the inhibition of CDKs and open new perspectives for their therapeutic applications.
___
Source: http://www.hubmed.org/display.cgi?uids=18761330
--
~
Powered by [5]RssFwd, a service of [6]Blue Sky Factory, Inc
Funny Tagalog Quotes and Funny Goodbye Letters
Freshen Up Your Day! Have some Humor and Funny Stuffs to Pump Up your Day! We All Need To Start On A Good Footing Every day.
Funny Tagalog Quotes, funny move poems and Funny Goodbye Letters as well as Really Funny Quick Jokes can quietly be found on the internet. Funny cards for family, friends and co-workers! Add your own personalized action and reaction. You can send all your funny ecards to your friends, coworkers, classmates and people around you. They keep their distance and including this,
there old friendship they will always miss.
They keep on hating and it's still unending,
what they don't recognize is that friendship is a blessing.
The action and reaction of this is to never hate,
the friends that you allow are your fate.
Funny Rude Free Ecards and funny response alerts can really make your day. Funny Goodbye Letters that you send to your coworkers and friends as well as your classmates can give them the humor they need.
Funny Goodbye Letters and where can I read funny text messages are always easy to mimic. At lunch time, sit in your parked car and point a hair dryer at passing cars to be informed if they slow down. Page yourself over the intercom. (Don't disguise your voice.)
Your here because you have need to send a greeting to someone you love and care about. You desire to send them an eCard! eCards are ambling to want, great fun and always arrive on time.
Wherefore my cheeks before their time are wan,
For very weeping is my gladness fled,
Sorrow hath paled my lip's vermilion,
And Ruin draws the curtains of my bed.
Download and Print - Once you let picked the eCard you wish to send, instead of emailing it you can also download and print it. This will give you the same great benefits of an eCard onto an actual paper card. Once printed the card will mildly fold into shape and be ready to hand deliver. Funny Car Commercials
It becomes to late to forgive and forget,
and loose the feeling of when they first met.
When they think the friendship is done,
the fighting is over and what starts is the fun.
Encourage your colleagues to join you in a little synchronized chair dancing. Make your garbage can on your desk and label it "IN." Develop an unnatural fear of staplers. Get decaf in the coffee maker for 3 weeks. Once everyone has gotten over their caffeine addictions, switch to espresso.
Funny gain ground sayings and sms friendship funny are notoriously seen all the time on webs this days. Even short funny rhyming poems and funny perception alerts too.
The latest innovation in the fields of science and technology has led to the development of a number of mind-boggling gadgets and gizmos. Take off clothes while sitting on bed and leave them in a pile.
Walk naked to bathroom. If wife seen, shake knob at her while shouting " path Hey!!"
Look in bear down on and suck in gut to imagine your manly physique.
Admire size of knob in maintain connection, scratch bollocks and smell fingers for one last whiff.
Foretell shower.
Friends are people who love each other,
forgive and forget one path or another.
Care no detail what,
not an 'if', 'and' or 'but'.
Do things without thinking,
that hurt people without blinking.
Carry you done funny plays sketches free skits UK? Funny prosper poems and Really Funny Quick Jokes can give the laughter you be obliged the rest of the day. Will no one tell me what she sings?–
Perhaps the plaintive numbers flow
For old, unhappy, far-off things,
And battles long ago:
Or is it some more frank lay,
Familiar feature of to-day?
Some natural sorrow, loss, or suffering,
That has been, and may be again?
Prosper sayings and Funny Tagalog Quotesare really the fun the notes and quotes nowadays and you can top it funny messages alerts and Funny Rude Free Ecards to spice the deal. But… I need I Need Some Funny Jokes Riddles For Teenagers.
Freshen Your Day. Watch and Upload Some Of Your Humor And Funny Stuffs, Funny Videos At aseanface.com
More Links and Info Sites For Your Searches
Funny Tagalog Quotes, Funny Short Skits, Funny Car Commercials
I Need Some Funny Jokes Riddles For Teenagers, Really Funny Quick Jokes
Funny Goodbye Letters, Funny Rude Free Ecards, Funny Sick Twisted Humor
Funny Videos and Entertainment
What Is The Average Price of Life Insurance
How Much Does Life Insurance Cost
aseanface.com , aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com
More financial Info Links
Life Insurance, Term Life Insurance, Life Insurance Quotes, Life Insurance Companies, Life Insurance UK, Over 50s Life Insurance, Tesco Life Insurance UK, Life Insurance Quote, Cheap Life Insurance In UK, How Does Life Insurance Works, How Much Does Life Insurance Cost, What Is The Average Price Of Life Insurance , Statistics Disability Insurance, Calculate A Mortgage, Mortgage Calculator UK, Student Loans, Mortgage, Motor Insurance Gravesend, Understanding Automobile Insurance, Mortgage Refinance In Ontario Canada, Car Insurance, What Is The Average Price of Life Insurance, How Much Does Life Insurance Cost
Thank You