Fwd: A Report by Leading Clinical Researchers on the Current Quantitative Imaging Tools for Lung Cancer Drug Assessment (Business Wire via Yahoo! Finance)

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From: Yahoo! News Search Results for lung cancer <rssfwd@rssfwd.com>
Date: Mon, Jun 30, 2008 at 6:26 AM
Subject: A Report by Leading Clinical Researchers on the Current Quantitative Imaging Tools for Lung Cancer Drug Assessment (Business Wire via Yahoo! Finance)
To: mesothelioma77@gmail.com


DUBLIN, Ireland----Research and Markets has announced the addition of the "Quantitative Imaging Tools for Lung Cancer Drug Assessment" report to their offering.

Mon, 30 Jun 2008 09:28:00 GMT

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Source: http://us.rd.yahoo.com/dailynews/rss/search/lung+cancer/SIG=11rp9ra0e/*http%3A//biz.yahoo.com/bw/080630/20080630005606.html?.v=1
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Fwd: Senators Chuck Hagel and Dianne Feinstein Make Lung Cancer Matter

---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Sat, Jun 28, 2008 at 4:00 PM
Subject: Senators Chuck Hagel and Dianne Feinstein Make Lung Cancer Matter
To: mesothelioma77@gmail.com

It's almost tantamount to July 4th, Independence Day, for Lung Cancer. For the first time, in the last four decades, Lung Cancer finally has a voice, thanks to Senators Chuck Hagel, Dianne Feinstein and the ...

Sat, 28 Jun 2008 07:00:00 GMT

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Source: http://www.topix.net/content/prweb/2008/06/senators-chuck-hagel-and-dianne-feinstein-make-lung-cancer-matter
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Fwd: Personality factors associated with psychological distress in testicular cancer survivors.

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From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Sat, Jun 28, 2008 at 4:00 PM
Subject: Personality factors associated with psychological distress in testicular cancer survivors.
To: mesothelioma77@gmail.com


[1]J Pers Assess. 2008 Jul; 90(4): 348-55
Siafaka V, Hyphantis TN, Alamanos I, Fountzilas G, Skarlos D, Pectasides D, Mavreas V, Pavlidis N

The aim of this study was to investigate symptoms of anxiety and depression in testicular cancer survivors (TCSs) and to identify personality traits associated with psychological distress in these patients by means of the MMPI (Hathaway & McKinley, 1943). A total of 50 TCSs and 50 age-adjusted healthy men participated in the study, and we used the following self-report instruments: Montgomery-Asberg Depression Rating Scale (Montgomery & Asberg, 1979), Hamilton Anxiety Rating Scale (Hamilton, 1959, 1969), Spielberger's State-Trait Anxiety Inventory (Spielberger, 1970, 2005), and the MMPI. TCSs displayed higher rates on all psychopathology scales studied compared to controls, but the majority of the patients' scores were within the "normal range," indicating rather mild psychological distress. TCSs' MMPI profiles showed higher rates on Scales 1, 3, 6, and 9 compared to controls; and within the TCSs sample, symptoms of depression were most closely associated with Scales 3 and 5. Similarly, anxiety symptoms were mainly associated with Scale 3. These findings indicate that TCSs present mild symptoms of psychological distress, mainly anxiety and depressive symptoms, suggesting that careful assessment and consultation in TC patients is essential to help them deal with distress after treatment and to minimize possible risk factors.



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Source: http://www.hubmed.org/display.cgi?uids=18584443
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Fwd: Conflicting evidence on the frequency of ESR1 amplification in breast cancer.

---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sat, Jun 28, 2008 at 4:00 PM
Subject: Conflicting evidence on the frequency of ESR1 amplification in breast cancer.
To: mesothelioma77@gmail.com


[1]Nat Genet. 2008 Jul; 40(7): 821-2
Albertson DG





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Source: http://www.hubmed.org/display.cgi?uids=18583976
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Fwd: Lost in translation-prognostic signatures for breast cancer.

---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sat, Jun 28, 2008 at 4:00 PM
Subject: Lost in translation-prognostic signatures for breast cancer.
To: mesothelioma77@gmail.com


[1]Nat Clin Pract Oncol. 2008 Jul; 5(7): 363
Pusztai L





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Source: http://www.hubmed.org/display.cgi?uids=18583992
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Fwd: ZIP7-mediated intracellular zinc transport contributes to aberrant growth factor signaling in anti-hormone resistant breast cancer cells.

---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sat, Jun 28, 2008 at 4:00 PM
Subject: ZIP7-mediated intracellular zinc transport contributes to aberrant growth factor signaling in anti-hormone resistant breast cancer cells.
To: mesothelioma77@gmail.com


[1]Endocrinology. 2008 Jun 26;
Taylor K, Vichova P, Jordan N, Hiscox S, Hendley R, Nicholson R

Anti-oestrogens such as Tamoxifen are the mainstay of treatment for oestrogen receptor positive breast cancer. However, their effectiveness is limited by the development of endocrine resistance, allowing tumour re-growth and progression. Importantly, in vitro MCF7 cell models of acquired tamoxifen resistance (TamR cells) display an aggressive, invasive phenotype in which activation of EGFR/IGF-1R/Src signalling plays a critical role. In this study, we report that TamR cells have increased levels of zinc and zinc transporter, ZIP7, resulting in an enhanced response to exogenous zinc which is manifested as a greatly increased growth factor receptor activation, leading to increased growth and invasion. Removal of ZIP7, using siRNA, destroys this activation of EGFR/IGF-1R/Src signalling by reducing intracellular zinc levels. Similarly it also blocks the activation of HER2, 3 and 4. This data suggests that intracellular zinc levels may be a critical factor in determining growth factor responses and that the targeting of zinc transporters may have novel therapeutic implications. We show that ZIP7 is a critical component in the redistribution of zinc from intracellular stores to the cytoplasm and, as such, is essential for the zinc-induced inhibition of phosphatases which leads to activation of growth factor receptors. Removal of ZIP7 therefore offers a means through which zinc-induced activation of growth factor receptors may be effectively suppressed and provides a mechanism of targeting multiple growth factor pathways, increasing tumour kill and preventing further development of resistance in breast cancer.



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Source: http://www.hubmed.org/display.cgi?uids=18583420
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Fwd: Biology and potential clinical implications of tissue inhibitor of metalloproteinases-1 in colorectal cancer treatment.

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Sat, Jun 28, 2008 at 4:00 PM
Subject: Biology and potential clinical implications of tissue inhibitor of metalloproteinases-1 in colorectal cancer treatment.
To: mesothelioma77@gmail.com


[1]Scand J Gastroenterol. 2008; 43(7): 774-86
Møller Sørensen N, Vejgaard Sørensen I, Ornbjerg Wurtz S, Schrohl AS, Dowell B, Davis G, Jarle Christensen I, Jørgen Nielsen H, Brunner N

Colorectal cancer (CRC) is the second leading cause of cancer-related death in the industrialized world. About half of "curatively" resected patients develop recurrent disease within the next 3-5 years despite the lack of clinical, histological and biochemical evidence of remaining overt disease after resection of the primary tumour. Availability of validated biological markers for early detection, selection for adjuvant therapy, prediction of treatment efficacy and monitoring of treatment efficacy would most probably increase survival. Tissue inhibitor of metalloproteinases-1 (TIMP-1) may be such a marker. TIMP-1 inhibits the proteolytic activity of metalloproteinases, which are centrally involved in tumour invasion and metastases. However, in clinical investigations high tumour tissue or plasma levels of TIMP-1 have shown a strong and independent association with a shorter survival time in CRC patients, suggesting that TIMP-1 could have a tumour-promoting function. Furthermore, measurement of plasma TIMP-1 has been shown to be useful for disease detection, with a high sensitivity and high specificity for early-stage colon cancer. This review describes some basic information on the current knowledge of the biology of TIMP-1 as well as the potential use of TIMP-1 as a biological marker in the management of CRC patients.



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Source: http://www.hubmed.org/display.cgi?uids=18584515
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