Asbestos Information Legal Mesothelioma Clinical: 09/15/08

Monday, September 15, 2008

Fwd: Consensus statement on peritoneal mesothelioma.

---------- Forwarded message ----------
From: HubMed - mesothelioma cancer <rssfwd@rssfwd.com>
Date: Sun, Aug 31, 2008 at 7:09 AM
Subject: Consensus statement on peritoneal mesothelioma.
To: mesothelioma77@gmail.com

[1]J Surg Oncol. 2008 Sep 15; 98(4): 268-72
Deraco M, Bartlett D, Kusamura S, Baratti D

Diffuse malignant peritoneal mesothelioma (DMPM) has been traditionally regarded as a rapidly lethal disease. Recently, several independent prospective trials have reported improved survival with an intensive loco-regional treatment strategy including cytoreductive surgery (CRS) along with peri-operative intra-peritoneal chemotherapy (PIC). However, most of the surgical data comes from mono-institutional phase I or II studies and there is a broad range of variability regarding inclusion criteria, cytoreductive surgical procedures, drugs, temperatures and methods of delivering the heated chemotherapy (open vs. closed abdomen). This manuscript critically analyze and discuss the results of a group of health care providers trying to achieve a consensus statement in the management of this group of patients. The main conflicting points regarding preoperative evaluation, patient eligibility, combined treatment methodology, postoperative follow-up and future investigational perspectives were summarized as a list of multiple-choice questions. A questionnaire was placed on the website of the "5(th) International Workshop on Peritoneal Surface Malignancies" and the group members voted via internet. The results were presented for further debate during a dedicated session of the Workshop. The general treatment guidelines and future investigational perspectives were defined.

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Source: http://www.hubmed.org/display.cgi?uids=18726890
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Fwd: Metastatic Appendiceal Mucinous Adenocarcinoma to Well-Differentiated Diffuse Mesothelioma of the Peritoneal Cavity: A Mimicker of Florid Mesothelial Hyperplasia in Association With Neoplasms.

---------- Forwarded message ----------
From: HubMed - mesothelioma cancer <rssfwd@rssfwd.com>
Date: Sun, Aug 31, 2008 at 7:09 AM
Subject: Metastatic Appendiceal Mucinous Adenocarcinoma to Well-Differentiated Diffuse Mesothelioma of the Peritoneal Cavity: A Mimicker of Florid Mesothelial Hyperplasia in Association With Neoplasms.
To: mesothelioma77@gmail.com

[1]Int J Gynecol Pathol. 2008 Aug 26;
Tran TA, Holloway RW, Finkler NJ

Atypical/florid mesothelial hyperplasia associated with another neoplastic process is not an infrequent phenomenon and has been reported in a variety of tumors. In those instances, the mesothelial proliferation might create a misdiagnosis of metastatic carcinoma but seldom raises the possibility of a well-differentiated mesothelioma seeded by metastatic neoplastic cells. Herein, we report the case of a 40-year-old woman originally diagnosed with exuberant atypical mesothelial hyperplasia after an diagnostic laparoscopy. The subsequent operation, however, demonstrated a mucinous neoplasm of the appendix with involvement of the peritoneal cavity in the form of peritoneal mucinous carcinomatosis as well as metastases to the uterine serosa and adnexal surfaces. Microscopic analysis revealed an appendiceal adenocarcinoma with signet-ring-cell features that has metastasized to a diffuse well-differentiated mesothelioma of the peritoneal cavity. In many areas, the atypical mesothelial proliferation is indistinguishable from florid mesothelial hyperplasia. The true nature of the mesothelial proliferation was only confirmed after extensive additional sampling, which showed unequivocal stromal invasion. To the best of our knowledge, this is the first report of a metastatic appendiceal mucinous adenocarcinoma to a well-differentiated diffuse mesothelioma of the peritoneal cavity. Although commonly associated with atypical/ florid mesothelial hyperplasia, a carcinoma can rarely metastasize to a well-differentiated mesothelioma, which can pose significant diagnostic difficulties because it can mimic a reactive process. This unusual case report expands the spectrum of mesothelial proliferation in conjunction with a malignant neoplasm and serves to remind pathologists that such a concomitant occurrence exists.

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Source: http://www.hubmed.org/display.cgi?uids=18753969
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Fwd: Novel oncolytic agent GLV-1h68 is effective against malignant pleural mesothelioma.

---------- Forwarded message ----------
From: HubMed - mesothelioma cancer <rssfwd@rssfwd.com>
Date: Sun, Aug 31, 2008 at 7:09 AM
Subject: Novel oncolytic agent GLV-1h68 is effective against malignant pleural mesothelioma.
To: mesothelioma77@gmail.com

[1]Hum Gene Ther. 2008 Aug; 19(8): 774-82
Kelly KJ, Woo Y, Brader P, Yu Z, Riedl C, Lin SF, Chen N, Yu YA, Rusch VW, Szalay AA, Fong Y

Malignant pleural mesothelioma (MPM) is a fatal disease with a median survival of less than 14 months. For the first time, a genetically engineered vaccinia virus is shown to produce efficient infection, replication, and oncolytic effect against MPM. GLV-1h68 is a replication-competent engineered vaccinia virus carrying transgenes encoding Renilla luciferase, green fluorescent protein (both inserted at the F14.5L locus), beta-galactosidase (inserted at the J2R locus, which encodes thymidine kinase), and beta-glucuronidase (at the A56R locus, which encodes hemagglutinin). This virus was tested in six human MPM cell lines (MSTO-211H, VAMT, JMN, H-2373, H-2452, and H-2052). GLV-1h68 successfully infected all cell lines. For the most sensitive line, MSTO-211H, expression of green fluorescent protein (GFP) started within 4 hr with increasing intensity over time until nearly 100% of cells expressed GFP at 24 hr. All cell lines were sensitive to killing by GLV-1h68, with the degree of sensitivity predictable by infectivity assay. Even the most resistant cell line exhibited 44 +/- 3.8% cell survival by day 7 when infected at a multiplicity of infection of 1.0. Viral proliferation assays demonstrated 2-to 4-fold logarithmic replication of GLV-1h68 in the cell lines tested. In an orthotopic model, GLV-1h68 effectively prevented development of cachexia and tumor-related morbidity, reduced tumor burden, and cured MPM in both early and late treatment groups. GLV-1h68 was successfully used to treat MPM in vitro and in an orthotopic model (in vivo). These promising results warrant clinical investigation of GLV-1h68 as a novel agent in the treatment of MPM.

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Source: http://www.hubmed.org/display.cgi?uids=18754710
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Fwd: Review of pemetrexed in combination with cisplatin for the treatment of malignant pleural mesothelioma.

---------- Forwarded message ----------
From: HubMed - mesothelioma cancer <rssfwd@rssfwd.com>
Date: Sun, Aug 31, 2008 at 7:09 AM
Subject: Review of pemetrexed in combination with cisplatin for the treatment of malignant pleural mesothelioma.
To: mesothelioma77@gmail.com

[1]Ther Clin Risk Manag. 2008 Feb; 4(1): 205-11
Goudar RK

Malignant pleural mesothelioma is a resistant form of lung cancer, and its incidence continues to rise in Europe and Australia. Until recently, chemotherapy had not been shown to be effective in the treatment of this slowly progressive disease. In 2004, the combination of pemetrexed and cisplatin was shown to induce high response rates in MPM. This article reviews the published literature describing the development and testing of this therapeutic combination in mesothelioma, and examines in detail the key phase III clinical trial that led to the approval of pemetrexed by the US FDA. Ongoing research will further define the role of pemetrexed plus cisplatin in the treatment of MPM.

___
Source: http://www.hubmed.org/display.cgi?uids=18728709
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Asbestos Information Legal Mesothelioma Clinical

Monday, September 15, 2008

Fwd: Consensus statement on peritoneal mesothelioma.

Fwd: Metastatic Appendiceal Mucinous Adenocarcinoma to Well-Differentiated Diffuse Mesothelioma of the Peritoneal Cavity: A Mimicker of Florid Mesothelial Hyperplasia in Association With Neoplasms.

Fwd: Novel oncolytic agent GLV-1h68 is effective against malignant pleural mesothelioma.

Fwd: Review of pemetrexed in combination with cisplatin for the treatment of malignant pleural mesothelioma.

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