Fwd: Asbestos in natural state focus of study (Hastings Gazette)

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From: Shell Enfesta <mesothelioma77@gmail.com>
Date: Feb 13, 2008 6:26 PM
Subject: Fwd: Asbestos in natural state focus of study (Hastings Gazette)
To: mesothelioma77.mesothelioma01@blogger.com

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From: Yahoo! News Search Results for mesothelioma <rssfwd@rssfwd.com>
Date: Feb 13, 2008 2:08 AM
Subject: Asbestos in natural state focus of study (Hastings Gazette)
To: mesothelioma77@gmail.com


Thousands of Australians may have been exposed to dangerous levels of asbestos simply by living or working around little known deposits of the substance, researchers say.

Wed, 13 Feb 2008 02:00:28 GMT

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Source: http://us.rd.yahoo.com/dailynews/rss/search/mesothelioma/SIG=128vdhkoj/*http%3A//wauchope.yourguide.com.au/articles/547726.html?src=topstories
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Fw: Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis.

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From: HubMed - mesothelioma <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Wednesday, February 13, 2008 1:59:58 AM
Subject: Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis.

[1]Trends Pharmacol Sci. 2008 Feb 8;
Egleton RD, Brown KC, Dasgupta P

Nicotinic acetylcholine receptors (nAChRs) constitute a heterogeneous family of ion channels that mediate fast synaptic transmission in neurons. They have also been found on non-neuronal cells such as bronchial epithelium and keratinocytes, underscoring the idea that they have functions well beyond neurotransmission. Components of cigarette smoke, including nicotine and NNK [4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone], are agonists of nAChRs. Given the association of tobacco use with several diseases, the non-neuronal nAChR signaling pathway has considerable implications for cancer and cardiovascular disease. Recent studies have shown that alpha7 is the main nAChR subunit that mediates the proliferative effects of nicotine in cancer cells. As a result, alpha7 nAChR might be a valuable molecular target for therapy of cancers such as lung cancer and mesothelioma. Future studies involving the design of nAChR antagonists with improved selectivity might identify novel strategies for the treatment of tobacco-related cancers. Here we review the cellular roles of non-neuronal nAChRs, including regulation of cell proliferation, angiogenesis, apoptosis, migration, invasion and secretion.



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Source: http://www.hubmed.org/display.cgi?uids=18262664
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Fw: [Expression of mesothelin as a potential diagnostic marker in mesothelioma]

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From: HubMed - mesothelioma <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Wednesday, February 13, 2008 1:59:58 AM
Subject: [Expression of mesothelin as a potential diagnostic marker in mesothelioma]

[1]Nihon Kokyuki Gakkai Zasshi. 2008 Jan; 46(1): 3-9
Kuribayashi K, Fukuoka K, Nakajima T, Miyake M, Miyata S, Tamura K, Iida S, Yamada S, Murakami A, Hirano H, Nakano T

Histological discrimination of mesothelioma from adenocarcinoma is often difficult, therefore, many investigators have tried immunohistochemical, ultrastructual, and molecular methods. Economically, immunohistological studies are more excellent, compared with ultrastractual and molecular biological methods. Immunohistologically, many well known markers are divided into two category; adenocarcinoma-related markers, which expressed by adenocarcinoma, and mesothelioma-related makers, which are positive for mesothelioma. CEA, TTF-1, and Ber-Ep4 are well known adenocarcinoma-related markers, mesothelin, TM, HBME-1 and calretinin, have been used as mesothelioma-related markers. Most previous reports associated with discrimination of adenocarcinoma and mesothelioma mentioned that a diagnosis of epithelioid mesothelioma would be excluded by the presence of adenocarcinoma-related antibody. The positive ratio of mesothelioma-related antibodies is lower than that of adenocarcinoma-related antibodies. Only a single mesothelioma-related marker cannot lead to a diagnosis of epithelioid mesothelioma and a correct diagnosis can be made by combination of several makers, which contain both mesothelioma-related markers and adenocarcinoma-related markers. We immunohistologically examined 41 cases of mesothelioma and 16 cases of adenocarcinoma of the lung, and re-evaluated the use of immunohistochemical markers, compared with previous reports. Reactivity for mesothelin was obtained in 19 (73%) of the epithelioid mesotheliomas, but none (0%) of the lung adenocarcinomas. None of the sarcomatoid mesotheliomas exhibited positivity for this marker, nor was any reactivity seen in the spindle cell component of the biphasic mesotheliomas. These findings indicate that, in some instances, mesothelin immunostaining can assist in the diagnosis of mesothelioma.



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Source: http://www.hubmed.org/display.cgi?uids=18260303
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Fw: Intensity-Modulated Radiotherapy for Resected Mesothelioma: The Duke Experience.

----- Forwarded Message ----
From: HubMed - mesothelioma <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Wednesday, February 13, 2008 1:59:58 AM
Subject: Intensity-Modulated Radiotherapy for Resected Mesothelioma: The Duke Experience.

[1]Int J Radiat Oncol Biol Phys. 2008 Feb 7;
Miles EF, Larrier NA, Kelsey CR, Hubbs JL, Ma J, Yoo S, Marks LB

PURPOSE: To assess the safety and efficacy of intensity-modulated radiotherapy (IMRT) after extrapleural pneumonectomy for malignant pleural mesothelioma. METHODS AND MATERIALS: Thirteen patients underwent IMRT after extrapleural pneumonectomy between July 2005 and February 2007 at Duke University Medical Center. The clinical target volume was defined as the entire ipsilateral hemithorax, chest wall incisions, including drain sites, and involved nodal stations. The dose prescribed to the planning target volume was 40-55 Gy (median, 45). Toxicity was graded using the modified Common Toxicity Criteria, and the lung dosimetric parameters from the subgroups with and without pneumonitis were compared. Local control and survival were assessed. RESULTS: The median follow-up after IMRT was 9.5 months. Of the 13 patients, 3 (23%) developed Grade 2 or greater acute pulmonary toxicity (during or within 30 days of IMRT). The median dosimetric parameters for those with and without symptomatic pneumonitis were a mean lung dose (MLD) of 7.9 vs. 7.5 Gy (p = 0.40), percentage of lung volume receiving 20 Gy (V(20)) of 0.2% vs. 2.3% (p = 0.51), and percentage of lung volume receiving 5 Gy (V(20)) of 92% vs. 66% (p = 0.36). One patient died of fatal pulmonary toxicity. This patient received a greater MLD (11.4 vs. 7.6 Gy) and had a greater V(20) (6.9% vs. 1.9%), and V(5) (92% vs. 66%) compared with the median of those without fatal pulmonary toxicity. Local and/or distant failure occurred in 6 patients (46%), and 6 patients (46%) were alive without evidence of recurrence at last follow-up. CONCLUSIONS: With limited follow-up, 45-Gy IMRT provides reasonable local control for mesothelioma after extrapleural pneumonectomy. However, treatment-related pulmonary toxicity remains a significant concern. Care should be taken to minimize the dose to the remaining lung to achieve an acceptable therapeutic ratio.



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Source: http://www.hubmed.org/display.cgi?uids=18262369
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