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Fw: Malignant pleural mesothelioma: utility of 18 F-FDG PET.

----- Forwarded Message ----
From: HubMed - mesothelioma <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Sunday, March 16, 2008 1:32:39 AM
Subject: Malignant pleural mesothelioma: utility of 18 F-FDG PET.

[1]Ann Ital Chir. 2007 Sep-Oct; 78(5): 393-6
Spitilli MG, Treglia G, Calcagni ML, Giordano A

Malignant Pleural Mesothelioma is a rare tumour that arise from the mesothelial cells of the pleura and in recent time the incidence of this disease is rising. Because of the implications for management and therapy, it is important to assess the accurate staging. 18F-fluorodeoxiglucose Positron Emission Tomography (18F-FDG PET) is become a useful tool in the diagnosis of many neoplasms, such as Malignant Pleural Mesothelioma. In particular it has been shown to be useful in the evaluation of the extent of pleural disease, in the establishment of lymph node involvement, in the evaluation of tumour invasion into the lung and thoracic wall, in the diagnosis of extrathoracic metastases, in the assessment of the response to treatment, and in planning radiotherapy. Developments in system technology, like improvements in hybrid system (integrated Positron Emission Tomography/Computed Tomography) and the discovery of new radiopharmaceuticals, promise to make PET much more useful and versatile in the future.

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Source: http://www.hubmed.org/display.cgi?uids=18338546
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Fw: Medico-legal aspects of mesothelioma.

----- Forwarded Message ----
From: HubMed - mesothelioma <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Sunday, March 16, 2008 1:32:38 AM
Subject: Medico-legal aspects of mesothelioma.

[1]Ann Ital Chir. 2007 Sep-Oct; 78(5): 401-3
Partemi S, De Giorgio F

The Authors, reviewing the Literature on asbestos-related Malignant Mesothelioma (MM), found that because of its very peculiar characteristics, the causal link between professional asbestos exposure and the development of this tumour is very difficult to define in respect to: diagnosis, causal link and individuation of possible culpable conducts. The evaluation of causal link in different medico-legal areas is studied by different criteria. In civil law the criterion of weak causality is followed to allow compensation for damages. For institutional purposes in INAIL, the definition of causal link is particularly facilitated by the legal presumption of origin. In fact it is sufficient, that asbestos-related lesions are ascertained in individuals who are or were exposed at any time of their professional life to the risk of inhaling asbestos fibres. In criminal law, the current approach of the Supreme Court is to demand evidence of strong causality, with a high logical probability and rational credibility, and beyond reasonable doubt, because criminal liability is personal as established in article 27 of the Italian Constitution. It is worth pointing out that all the levels of evidence indicated above must pass the test of scientific suitability or possibility.

___
Source: http://www.hubmed.org/display.cgi?uids=18338548
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Fwd: LegalView Mesothelioma Blog Reports on Whistleblower Who Was...

---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Fri, Apr 18, 2008 at 5:33 AM
Subject: LegalView Mesothelioma Blog Reports on Whistleblower Who Was...
To: mesothelioma77@gmail.com

LegalView recently updated its mesothelioma blog to include reports of a whistleblower being fired after he reported improper asbestos cleanup.

Fri, 18 Apr 2008 07:24:08 GMT

Source: http://www.prweb.com/releases/2008/04/prweb870094.htm
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Fwd: Combined effect of GSTM1, GSTT1 and GSTP1 polymorphisms on histological subtypes of lung cancer.

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Fri, Apr 18, 2008 at 5:34 AM
Subject: Combined effect of GSTM1, GSTT1 and GSTP1 polymorphisms on histological subtypes of lung cancer.
To: mesothelioma77@gmail.com

[1]Biomarkers. 2008 May-Jun; 13(3): 282-95
Sobti RC, Kaur P, Kaur S, Janmeja AK, Jindal SK, Kishan J, Raimondi S

Genetic polymorphisms are natural genetic variations in the gene sequence that occur at a frequency of >1% in the population. This genetic variability (polymorphisms) can be a factor in cancer risk. The functional polymorphisms in GST genes play an important role in susceptibility to lung cancer. In our previous study, we reported that the combination of certain genotypes of GSTM1, GSTT1 and CYP1A1 is associated with lung cancer. The study has been extended to investigate the potential role of polymorphism in GSTP1 alone or in combination with the status of GSTM1 and GSTT1 genes in the likelihood of development of lung cancer. A total of 302 subjects (151 cases and 151 controls) were evaluated. Using a case-control design, individuals were genotyped for GSTs using multiplex polymerase chain reaction and restriction fragment length polymorphism techniques. The data obtained were analyzed using multiple logistic regression. The combined 'at risk' genotypes of GSTM1 null and GSTT1 null in comparison with 'wild-type' genotypes seems to be associated with a greater risk of lung cancer, but the results are not significant (odds ratio (OR) 2.0, 95% confidence interval (CI) 0.68-5.96) and for squamous cell carcinoma (SqCC) it was 1.6-fold (OR 1.6, 95% CI 0.49-5.68). In summary, our case-control study of lung cancer revealed that the effect of these polymorphisms is not very marked for different genotypic combinations of GSTP1, GSTM1 and GSTT1 in the context of developing lung cancer in a north Indian population. However, the increased risk was limited to SqCC, and was not found for other histological subtypes. Further analyses on this topic are needed.

___
Source: http://www.hubmed.org/display.cgi?uids=18415801
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Fwd: Neuropsychological Sequelae of Non-Central Nervous System Cancer and Cancer Therapy.

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Fri, Apr 18, 2008 at 5:34 AM
Subject: Neuropsychological Sequelae of Non-Central Nervous System Cancer and Cancer Therapy.
To: mesothelioma77@gmail.com

[1]Neuropsychol Rev. 2008 Apr 16;
Wefel JS, Witgert ME, Meyers CA

Cancer patients report numerous adverse symptoms associated with their disease and treatment including cognitive dysfunction, fatigue, and affective distress. Cognitive dysfunction is ubiquitous in patients with primary central nervous system (CNS) cancer and recent evidence has documented similar deficits in patients with non-CNS cancer as well. Both the cancer itself and treatments including chemotherapy, biological response modifiers, and hormonal therapies have been demonstrated to adversely impact cognitive and neurobehavioral function. Neuroimaging and neurophysiological investigations have likewise revealed alterations in brain function that are helping to account for the nature of these cognitive disorders. Similarly, preclinical animal research is assisting to identify the pathophysiological mechanisms that underlie treatment-related neurotoxicities. The coalescence of multidisciplinary clinical and research efforts hold promise for the development of interventions that may offer neuroprotection in addition to currently available symptomatic therapies and cognitive rehabilitation techniques.

___
Source: http://www.hubmed.org/display.cgi?uids=18415683
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Fwd: Early onset breast cancer in black British women: a letter to the editor of British Journal of Cancer regarding early onset of breast cancer in a group of British black women.

---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Fri, Apr 18, 2008 at 5:34 AM
Subject: Early onset breast cancer in black British women: a letter to the editor of British Journal of Cancer regarding early onset of breast cancer in a group of British black women.
To: mesothelioma77@gmail.com

[1]Br J Cancer. 2008 Apr 22; 98(8): 1482
Dindyal S, Ramdass MJ, Naraynsingh V

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Source: http://www.hubmed.org/display.cgi?uids=18414474
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