Fw: Novel dual targeting strategy with vandetanib induces tumor cell apoptosis and inhibits angiogenesis in malignant pleural mesothelioma cells expressing RET oncogenic rearrangement.

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From: HubMed - mesothelioma <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Friday, March 28, 2008 2:50:31 PM
Subject: Novel dual targeting strategy with vandetanib induces tumor cell apoptosis and inhibits angiogenesis in malignant pleural mesothelioma cells expressing RET oncogenic rearrangement.

[1]Cancer Lett. 2008 Mar 23;
Ogino H, Yano S, Kakiuchi S, Yamada T, Ikuta K, Nakataki E, Goto H, Hanibuchi M, Nishioka Y, Ryan A, Sone S

Malignant pleural mesothelioma (MPM) is an aggressive malignancy with a poor prognosis, therefore development of novel effective therapies is urgent. In the present study, we investigated the therapeutic efficacy of vandetanib (ZD6474), an inhibitor of VEGFR-2, EGFR and RET tyrosine kinases, in an orthotopic model of MPM. We found that a human MPM cell line, EHMES-10, expressed RET/PTC3 oncogenic rearrangement and a large amount of VEGF. Vandetanib induced the apoptosis and inhibited the proliferation of EHMES-10 cells in vitro (IC(50)=0.3muM). Once-daily oral treatment with vandetanib inhibited tumor angiogenesis, and reduced significantly the growth of thoracic tumors and the production of pleural effusions, resulting in the prolonged survival of mice in EHMES-10 orthograft model. In contrast, the selective EGFR tyrosine kinase inhibitor, gefitinib, had no effect against EHMES-10 cells both in vitro and in vivo. Our results suggest that using vandetanib to target RET-dependent tumor cell proliferation and survival and VEGFR-2-dependent tumor angiogenesis may be promising against MPM expressing RET oncogenic rearrangement and VEGF.



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Fw: Cell-cycle molecules in mesothelioma: an overview.

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From: HubMed - mesothelioma <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Friday, March 28, 2008 2:50:31 PM
Subject: Cell-cycle molecules in mesothelioma: an overview.

[1]J Exp Clin Cancer Res. 2007 Dec; 26(4): 443-9
Spugnini EP, Campioni M, D'Avino A, Caruso G, Citro G, Baldi A

Cell cycle progression is mediated by a group of proteins named cyclins that activate a highly conserved family of protein kinases, the cyclin-dependent kinases (CDKs). CDKs are also regulated by related proteins called cdk inhibitors, grouped into two families: the INK4 inhibitors (p16, p15, p19 and p18) and the Cip/Kip inhibitors (p21, p27). Moreover, several tumour suppressor genes (such as Retinoblastoma gene and p53 gene) are implicated in the regulation of the molecular mechanism of cell division. Several studies report the importance of cell cycle regulator proteins in the pathogenesis and the prognosis of mesothelioma. This article will review the most recent data from the literature about the expression and the diagnostic and prognostic significance of cell cycle molecules in mesothelioma.



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Fw: New Weblog Aims To Raise Awareness Of Deadly Form Of Lung Cancer

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From: Search for mesothelioma diagnosis <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Thursday, March 27, 2008 3:23:33 PM
Subject: New Weblog Aims To Raise Awareness Of Deadly Form Of Lung Cancer

Main Category: Lung Cancer Also Included In: IT / Internet / E-mail Article Date: 27 Mar 2008 Current statistics show 2,000-3,000 people are diagnosed with malignant pleural mesothelioma in the U.S. each year, ...

Thu, 27 Mar 2008 12:03:43 GMT

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Source: http://www.medilexicon.com/medicalnews.php?newsid=101886
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Fwd: Asbestos compensation case begins (Channel 4)

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From: Yahoo! News Search Results for asbestos cancer <rssfwd@rssfwd.com>
Date: Thu, Jun 5, 2008 at 1:35 AM
Subject: Asbestos compensation case begins (Channel 4)
To: mesothelioma77@gmail.com


A High Court battle begins between the families of asbestos-related cancer victims and employers' insurers who say they are not liable to pay compensation.

Tue, 03 Jun 2008 08:27:35 GMT

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Source: http://us.rd.yahoo.com/dailynews/rss/search/asbestos+cancer/SIG=1321ot6ug/*http%3A//www.channel4.com/news/articles/society/health/asbestos+compensation+case+begins/2269082
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Fwd: Asbestos legal case begins (BBC News)

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From: Yahoo! News Search Results for asbestos cancer <rssfwd@rssfwd.com>
Date: Thu, Jun 5, 2008 at 1:35 AM
Subject: Asbestos legal case begins (BBC News)
To: mesothelioma77@gmail.com


A legal battle over compensation for asbestos victims is due to start in the High Court.

Tue, 03 Jun 2008 06:41:40 GMT

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Source: http://us.rd.yahoo.com/dailynews/rss/search/asbestos+cancer/SIG=11q699c90/*http%3A//news.bbc.co.uk/go/rss/-/2/hi/health/7431207.stm
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Fwd: Lung asbestos content in lungs resected for primary lung cancer.

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From: HubMed - asbestos cancer <rssfwd@rssfwd.com>
Date: Thu, Jun 5, 2008 at 1:36 AM
Subject: Lung asbestos content in lungs resected for primary lung cancer.
To: mesothelioma77@gmail.com


[1]J Thorac Oncol. 2008 Jun; 3(6): 569-76
Wright CM, Bowman RV, Tan ME, Martins MU, McLachlan RE, Passmore LH, Windsor MN, Clarke BE, Duhig EE, Mahar AM, Fong K

INTRODUCTION: The majority of Australia's burden of lung cancer occurs in current or former tobacco smokers. To determine the possible contribution of asbestos exposure in Australians presenting with primary lung cancer, we measured lung asbestos content in cases resected consecutively at a single cardio-thoracic hospital. METHODS: Asbestos bodies were quantified by lung tissue digestion, filtration, and light microscopy, and were correlated with exposure questionnaires and clinicopathological features. RESULTS: We demonstrate high intrarater reproducibility and interrater reliability using these methods. In 463 patients with resected primary lung cancers, asbestos content ranged from 0 to 749 asbestos bodies per gram wet weight (AB/gww). Forty-eight percent of patients had no asbestos bodies identified. One-third had less than or equal to 20 AB/gww (a level previously found to be consistent with urban dwelling). Nineteen percent had lung content in excess of this level. Only 20 cases had AB >100/gww, approximately equivalent to the Helsinki threshold for attribution of lung cancer to asbestos. Median asbestos body counts were higher in patients who reported previous asbestos exposure than in those who reported no exposure. A subgroup of cases gave detailed exposure histories that did not predict presence or absence of asbestos bodies in men or women. In cases with cumulative tobacco exposure less than 20 pack-years, asbestos body counts exceeding 20 AB/gww were overrepresented. CONCLUSIONS: We found that the majority of patients with primary lung cancer at a single Australian center have detectable asbestos in resected lung tissue, but fiber burdens are generally low. The contributory role of this low-level asbestos exposure in causing lung cancer remains uncertain.



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Source: http://www.hubmed.org/display.cgi?uids=18520793
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Fwd: Evaluation of the Webler-Brown model for estimating tetrachloroethylene exposure from vinyl-lined asbestos cement pipes.

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From: HubMed - asbestos cancer <rssfwd@rssfwd.com>
Date: Thu, Jun 5, 2008 at 1:36 AM
Subject: Evaluation of the Webler-Brown model for estimating tetrachloroethylene exposure from vinyl-lined asbestos cement pipes.
To: mesothelioma77@gmail.com


[1]Environ Health. 2008 Jun 2; 7(1): 24
Spence LA, Aschengrau A, Gallagher LE, Webster TF, Heeren TC, Ozonoff DM

ABSTRACT: BACKGROUND: From May 1968 through March 1980, vinyl-lined asbestos-cement (VL/AC) water distribution pipes were installed in New England to avoid taste and odor problems associated with asbestos-cement pipes. The vinyl resin was applied to the inner pipe surface in a solution of tetrachloroethylene (perchloroethylene, PCE). Substantial amounts of PCE remained in the liner and subsequently leached into public drinking water supplies. METHODS: Once aware of the leaching problem and prior to remediation (April-November 1980), Massachusetts regulators collected drinking water samples from VL/AC pipes to determine the extent and severity of the PCE contamination. This study compares newly obtained historical records of PCE concentrations in water samples (n=88) with concentrations estimated using an exposure model employed in epidemiologic studies on the cancer risk associated with PCE-contaminated drinking water. The exposure model was developed by Webler and Brown to estimate the mass of PCE delivered to subjects' residences. RESULTS: The mean and median measured PCE concentrations in the water samples were 66 and 0.5mug/L, respectively, and the range extended from non-detectable to 2432 mug/L. The model-generated concentration estimates and water sample concentrations were moderately correlated (Spearman rank correlation coefficient= 0.48, p

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Fwd: The lived experience of patients with pleural mesothelioma.

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From: HubMed - asbestos cancer <rssfwd@rssfwd.com>
Date: Sat, Jun 7, 2008 at 2:25 AM
Subject: The lived experience of patients with pleural mesothelioma.
To: mesothelioma77@gmail.com


[1]Int J Palliat Nurs. 2008 Feb; 14(2): 66-71
Hughes N, Arber A

This paper reports on a research study of five patients diagnosed with mesothelioma. The study used a phenomenological approach to explore patients' lived experience using in-depth interviews. The findings identify that patients have many unmet psychosocial and emotional needs and that there was a lack of information provided to patients about specialist supportive and palliative care services. A number of the patients found specialist supportive care by chance rather than by referral. In addition, patients were involved in complex medico-legal matters in relation to asbestos exposure, and this was an additional burden for them and their spouse or carer. A feeling of social isolation was also reported and a number of patients would welcome the opportunity to meet with other people in the same situation as themselves. In conclusion, there is a lack of attention to the emotional needs of this group of patients, which means that supportive care resources are not being accessed in a timely and flexible manner.



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Source: http://www.hubmed.org/display.cgi?uids=18414321
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