Fw: Establishment of a novel specific ELISA system for rat N- and C-ERC/mesothelin. Rat ERC/mesothelin in the body fluids of mice bearing mesothelioma.

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From: HubMed - mesothelioma <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Tuesday, February 26, 2008 9:54:05 PM
Subject: Establishment of a novel specific ELISA system for rat N- and C-ERC/mesothelin. Rat ERC/mesothelin in the body fluids of mice bearing mesothelioma.

[1]Cancer Sci. 2008 Feb 24;
Hagiwara Y, Hamada Y, Kuwahara M, Maeda M, Segawa T, Ishikawa K, Hino O

Mesothelioma is a type of malignant tumor that most commonly arises from the pleural or peritoneal membrane and is usually associated with previous exposure to asbestos. In humans, ERC/mesothelin is expressed on the normal mesothelium and in some cancers such as mesothelioma or ovarian carcinoma. Recently, several enzyme-linked immunosorbent assay (ELISA) systems for ERC/mesothelin have been developed, the reported usefulness of which has been assessed and demonstrated as a diagnostic tool. However, the basic roles or physiological functions of, and relationship between, ERC/mesothelin and asbestos exposure-mediated carcinogenesis remain to be resolved. In order to elucidate the precise mechanism, animal models of mesothelioma are desperately needed. In this study, we consider the development of a novel specific ELISA system for not only rat N-ERC/mesothelin but also C-ERC/mesothelin, and the first data on the presence of rat ERC/mesothelin in the body fluids of rat malignant mesothelioma-bearing nude mice. The transplanted mice have revealed the higher concentrations of rat N-ERC/mesothelin in the blood and ascites than C-ERC/mesothelin. We hope these novel ELISA systems are useful in the rat model system to clarify the mechanism of asbestos-induced carcinogenesis and to develop new effective drugs for mesothelioma.



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Source: http://www.hubmed.org/display.cgi?uids=18294289
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Fwd: Key dates in Kosovo's drive for independence

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From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Sat, Feb 16, 2008 at 7:08 PM
Subject: Key dates in Kosovo's drive for independence
To: mesothelioma77@gmail.com

The Key dates in Kosovo's decades-long - and often bloody - drive to gain independence from Serbia: 1968: First pro-independence demonstrations by ethnic Albanians in Kosovo, when it was part of Yugoslavia; ...

Sat, 16 Feb 2008 22:07:47 GMT

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Source: http://www.theglobeandmail.com/servlet/story/RTGAM.20080216.kosovotimeline0216/BNStory/Front
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Fwd: Don't Look to Supplements for Cancer Protection

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From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Sat, Feb 16, 2008 at 7:08 PM
Subject: Don't Look to Supplements for Cancer Protection
To: mesothelioma77@gmail.com

Experts at the American Institute for Cancer Research said today that whole foods, and not dietary supplements, play a role in lowering cancer risk.

Sat, 16 Feb 2008 14:48:19 GMT

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Source: http://www.infozine.com/news/stories/op/storiesView/sid/27019/
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Fwd: Rapid activation of ERK1/2 and AKT in human breast cancer cells by cadmium.

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From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sat, Feb 16, 2008 at 7:08 PM
Subject: Rapid activation of ERK1/2 and AKT in human breast cancer cells by cadmium.
To: mesothelioma77@gmail.com


[1]Toxicol Appl Pharmacol. 2007 Dec 27;
Liu Z, Yu X, Shaikh ZA

Cadmium (Cd), an endocrine disruptor, can induce a variety of signaling events including the activation of ERK1/2 and AKT. In this study, the involvement of estrogen receptors (ER) in these events was evaluated in three human breast caner cell lines, MCF-7, MDA-MB-231, and SK-BR-3. The Cd-induced signal activation patterns in the three cell lines mimicked those exhibited in response to 17beta-estradiol. Specifically, treatment of MCF-7 cells, that express ERalpha, ERbeta and GPR30, to 0.5-10 muM Cd for only 2.5 min resulted in transient phosphorylation of ERK1/2. Cd also triggered a gradual increase and sustained activation of AKT during the 60 min treatment period. In SK-BR-3 cells, that express only GPR30, Cd also caused a transient activation of ERK1/2, but not of AKT. In contrast, in MDA-MB-231 cells, that express only ERbeta, Cd was unable to cause rapid activation of either ERK1/2 or AKT. A transient phosphorylation of ERalpha was also observed within 2.5 min of Cd exposure in the MCF-7 cells. While the estrogen receptor antagonist, ICI 182,780, did not prevent the effect of Cd on these signals, specific siRNA against hERalpha significantly reduced Cd-induced activation of ERK1/2 and completely blocked the activation of AKT. It is concluded that Cd, like estradiol, can cause rapid activation of ERK1/2 and AKT and that these signaling events are mediated by possible interaction with membrane ERalpha and GPR30, but not ERbeta.



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Source: http://www.hubmed.org/display.cgi?uids=18275979
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Fwd: Mesothelioma stories about asbestos products

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From: blinkx SmartFeed: mesothelioma cancer <rssfwd@rssfwd.com>
Date: Tue, Feb 19, 2008 at 7:35 AM
Subject: Mesothelioma stories about asbestos products
To: mesothelioma77@gmail.com


Mesothelioma stories.1952 video describe building sidewalls from asbestos. More mesothelioma stories about mesothelioma cancer cause by asbestos exposure at...

smartfeed@blinkx.com Sun, 17 Feb 2008 17:13:54 GMT

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Source: http://www.blinkx.com/video/MySpace/Mesothelioma_stories_about_asbestos_products~vHnahg_dw4LhphubDHbx-kg&referrer=website_rss
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Fwd: Crunchy goodness

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From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Sat, Feb 16, 2008 at 7:08 PM
Subject: Crunchy goodness
To: mesothelioma77@gmail.com

Carrots are good. Munch on them raw or cook them in milk, they are a rich source of nutrients and low in calories too.

Sat, 16 Feb 2008 22:54:53 GMT

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Source: http://www.indianexpress.com/story/273348.html
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Fwd: Cancer 'coaches' sway treatment choices

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From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Sat, Feb 16, 2008 at 7:08 PM
Subject: Cancer 'coaches' sway treatment choices
To: mesothelioma77@gmail.com

The advice made her head spin: Have the lump removed. No, let them take the whole breast.

Sat, 16 Feb 2008 22:14:03 GMT

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Source: http://www.kidk.com/news/health/15701182.html
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