From: Shell Enfesta <shell8377@yahoo.com>
To: mesothelioma77.mesothelioma07@blogger.com
Sent: Wednesday, February 13, 2008 7:03:39 AM
Subject: Fw: Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis.
From: HubMed - mesothelioma <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Wednesday, February 13, 2008 1:59:58 AM
Subject: Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis.
[1]Trends Pharmacol Sci. 2008 Feb 8;
Egleton RD, Brown KC, Dasgupta P
Nicotinic acetylcholine receptors (nAChRs) constitute a heterogeneous family of ion channels that mediate fast synaptic transmission in neurons. They have also been found on non-neuronal cells such as bronchial epithelium and keratinocytes, underscoring the idea that they have functions well beyond neurotransmission. Components of cigarette smoke, including nicotine and NNK [4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone], are agonists of nAChRs. Given the association of tobacco use with several diseases, the non-neuronal nAChR signaling pathway has considerable implications for cancer and cardiovascular disease. Recent studies have shown that alpha7 is the main nAChR subunit that mediates the proliferative effects of nicotine in cancer cells. As a result, alpha7 nAChR might be a valuable molecular target for therapy of cancers such as lung cancer and mesothelioma. Future studies involving the design of nAChR antagonists with improved selectivity might identify novel strategies for the treatment of tobacco-related cancers. Here we review the cellular roles of non-neuronal nAChRs, including regulation of cell proliferation, angiogenesis, apoptosis, migration, invasion and secretion.
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Source: http://www.hubmed.org/display.cgi?uids=18262664
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Treatment for Mesothelioma: Surgery is the most common therapy for mesothelioma, because most cases are well advanced by the time they are discovered. Surgery usually entails removal of part of the protective sac surrounding the organ, as well as a portion of the organ tissue. In some cases part of the diaphragm may also be removed. Basically, it all depends on how far the cancer has spread. In some rarer cases, one entire lung must be removed. Other treatments for mesothelioma include radiation therapy and chemotherapy. These two types of cancer treatment are common, but very risky. They cause many painful side effects, and are typically only given for short periods of time to avoid complete deterioration of the overall health of the patient.
Lawsuits over Mesothelioma: There have been many lawsuits regarding cases of mesothelioma, especially in recent years. This is because the known effects of asbestos have been known for decades, and many employers and asbestos manufacturers have failed to recognize or prevent asbestos exposure. When safety measures are not taken and guidelines not met, the employer or manufacturer becomes liable for the mesothelioma in the patient. These lawsuits usually end with large settlements for the patients to help cover medical bills, loss of wages, or even loss of income for family left behind in wrongful death lawsuits.
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