Monday, March 10, 2008

Fw: Leading Asbestos-Cancer Group Urges Congress to Partner with Them and ...



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From: Search for mesothelioma diagnosis <rssfwd@rssfwd.com>
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Sent: Thursday, February 28, 2008 2:02:45 PM
Subject: Leading Asbestos-Cancer Group Urges Congress to Partner with Them and ...

The Meso Foundation is urging the House of Representatives to move expeditiously and step-up to the plate in allocating research funds for mesothelioma and partner with the Meso Foundation in developing ...

Thu, 28 Feb 2008 16:56:13 GMT

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Source: http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=109&STORY=/www/story/02-28-2008/0004764619&EDATE=
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Fw: Pleural mesothelioma: diagnostic problems and evaluation of prognostic factors.



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From: HubMed - mesothelioma diagnosis <rssfwd@rssfwd.com>
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Sent: Thursday, February 28, 2008 2:03:44 PM
Subject: Pleural mesothelioma: diagnostic problems and evaluation of prognostic factors.

[1]J Egypt Natl Canc Inst. 2006 Dec; 18(4): 303-10
Ismail HM, A Nouh MA, Abulkheir IL, Abd El-Rahman Ael-R, Tawfik HN

Background: Malignant pleural mesothelioma (MPM) in Egypt is mainly attributed to an environmental origin i.e exposure to asbestos, with a high incidence in women and young adults. Immunohistochemistry and ultrastructural features aid in the diagnosis. The p27Kip1 is a kinase inhibitor protein acting as a cell cycle regulator and a putative tumor suppressor gene playing a critical role in the pathogenesis of several human neoplasms. Aim: A clinicopathologic, immunohistochemical and ultrastructural study of mesothelioma in Egyptian patients, with identification of different prognostic factors. Material and Methods: Sixty-one cases of MPM were collected from the department of pathology at the NCI, Cairo. Cases were stained by monoclonal antibodies against CK5 /6, calretinin, vimentin, CD15, CEA and p27. Results: More than half (57.4%) of the patients were residents in endemic areas; 50.8% were of epithelioid type. CK5 / 6 was positive in 45 (73.8%) cases, 39 (63.9%) cases were positive for vimentin, 49 (80.3%) cases were positive for calretinin. One case showed a focal weak positive reaction to CD15. None of the cases stained for CEA. There was a statistically significant relation between p27 expression and the histopathologic type (p =0.02) between overall survival and age (p = 0.01), histopathologic type (p =0.02) and stage (p =0.006). Conclusion: MPM is an increasing disaster in Egypt which is underestimated and neglected. A panel of immunohistochemical markers should be used for proper evaluation. p27 has proven to be a potential biologic prognostic marker for mesothelioma and more studies as regard its significance are recommended on a larger number. Key Words: Mesothelioma - Asbestos - CK5 / 6 - Calretinin- p27.



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Source: http://www.hubmed.org/display.cgi?uids=18301454
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Fwd: Acquired and Innate Resistance to the Cancer-Specific Apoptosis-Inducing Cytokine, mda-7/IL-24: Not Insurmountable Therapeutic Problems.



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Date: Sat, Feb 16, 2008 at 8:08 PM
Subject: Acquired and Innate Resistance to the Cancer-Specific Apoptosis-Inducing Cytokine, mda-7/IL-24: Not Insurmountable Therapeutic Problems.
To: mesothelioma77@gmail.com


[1]Cancer Biol Ther. 2008 Feb 5; 7(4):
Sarkar D, Dent P, Curiel DT, Fisher PB





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Source: http://www.hubmed.org/display.cgi?uids=18277093
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Fwd: Nexavar Dropped From Lung Cancer Trial (Medical News Today)



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From: Yahoo! News Search Results for lung cancer <rssfwd@rssfwd.com>
Date: Tue, Feb 19, 2008 at 8:35 AM
Subject: Nexavar Dropped From Lung Cancer Trial (Medical News Today)
To: mesothelioma77@gmail.com


Bayer HealthCare Pharmaceuticals and Onyx Pharmaceuticals have stopped a late stage trial of their cancer drug Nexavar (sorafenib) in patients with nonsmall-cell lung cancer (NSCLC), because it was not showing the hoped for increase in survival.

Tue, 19 Feb 2008 12:13:29 GMT

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Fwd: Silicosis prevalence among gold miners continues to soar, study finds (Independent Online)



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Date: Sun, Feb 17, 2008 at 6:00 PM
Subject: Silicosis prevalence among gold miners continues to soar, study finds (Independent Online)
To: mesothelioma77@gmail.com


South Africa's gold mining industry has been damned as the biggest contributor to the prevalence of silicosis, which in six years has almost doubled in both black and white mine workers, a study of autopsies conducted in 2006 by the National Institute for Occupational Health has found.

Sun, 17 Feb 2008 05:26:55 GMT

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