Fwd: Dr. Paul Donohue: The best screening for lung cancer remains controversial (Detroit News)

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From: Yahoo! News Search Results for lung cancer <rssfwd@rssfwd.com>
Date: Fri, Aug 1, 2008 at 4:31 PM
Subject: Dr. Paul Donohue: The best screening for lung cancer remains controversial (Detroit News)
To: mesothelioma77@gmail.com


Dear Dr. Donohue: I am a 69-year-old woman in fairly good health. I stopped smoking 19 years ago. My brother and two of my sisters have died from lung cancer. My sisters smoked until the diagnosis, but my brother hadn't smoked in 40 years. I have had two MRI scans for back problems and two spiral CT scans looking for lung cancer. My doctor was not in favor of the two CT scans. I asked about ...

Thu, 31 Jul 2008 05:30:22 GMT

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Source: http://us.rd.yahoo.com/dailynews/rss/search/lung+cancer/SIG=12i1mvbvf/*http%3A//www.detnews.com/apps/pbcs.dll/article?AID=/20080731/OPINION03/807310402
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Fwd: Lung cancer study launched (Channel 4)

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From: Yahoo! News Search Results for lung cancer <rssfwd@rssfwd.com>
Date: Fri, Aug 1, 2008 at 4:31 PM
Subject: Lung cancer study launched (Channel 4)
To: mesothelioma77@gmail.com


A study identifying lung cancer patients at risk of relapsing is to be launched in Northern Ireland. The genetic research could be submitted for international approval by 2010, according to an expert from Almac Diagnostics.

Fri, 01 Aug 2008 16:40:58 GMT

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Fwd: Best screening for lung cancer remains controversial (Chattanooga Times Free Press)

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From: Yahoo! News Search Results for lung cancer <rssfwd@rssfwd.com>
Date: Fri, Aug 1, 2008 at 4:31 PM
Subject: Best screening for lung cancer remains controversial (Chattanooga Times Free Press)
To: mesothelioma77@gmail.com


DEAR DR. DONOHUE: I am a 69-year-old woman in fairly good health. I stopped smoking 19 years ago. My brother and two of my sisters have died from lung cancer.

Thu, 31 Jul 2008 04:10:21 GMT

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Fwd: Fundraiser Planned For Cincinnati CSI Cop with Cancer (Local 12 Cincinnati)

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From: Yahoo! News Search Results for lung cancer <rssfwd@rssfwd.com>
Date: Fri, Aug 1, 2008 at 4:31 PM
Subject: Fundraiser Planned For Cincinnati CSI Cop with Cancer (Local 12 Cincinnati)
To: mesothelioma77@gmail.com


Spencer Henderson has lung cancer that has spread to his brain

Fri, 01 Aug 2008 16:01:44 GMT

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Fwd: Fundraiser slated for cancer patient (Northwest Herald)

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Date: Fri, Aug 1, 2008 at 4:31 PM
Subject: Fundraiser slated for cancer patient (Northwest Herald)
To: mesothelioma77@gmail.com


CARY – A Friday fundraiser will benefit a local woman with stage-four lung cancer.

Fri, 01 Aug 2008 13:40:24 GMT

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Fwd: [(18)F]FDG and [(18)F]FLT uptake in human breast cancer cells in relation to the effects of chemotherapy: an in vitro study.

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Date: Fri, Aug 1, 2008 at 4:32 PM
Subject: [(18)F]FDG and [(18)F]FLT uptake in human breast cancer cells in relation to the effects of chemotherapy: an in vitro study.
To: mesothelioma77@gmail.com


[1]Br J Cancer. 2008 Jul 29;
Direcks WG, Berndsen SC, Proost N, Peters GJ, Balzarini J, Spreeuwenberg MD, Lammertsma AA, Molthoff CF

Increased 2'-deoxy-2'-[(18)F]fluoro-D-glucose (FDG) uptake is the most commonly used marker for positron emission tomography in oncology. However, a proliferation tracer such as 3'-deoxy-3'-[(18)F]fluorothymidine (FLT) might be more specific for cancer. 3'-deoxy-3'-[(18)F]fluorothymidine uptake is dependent on thymidine kinase 1 (TK) activity, but the effects of chemotherapeutic agents are unknown. The aim of this study was to characterise FDG and FLT uptake mechanisms in vitro before and after exposure to chemotherapeutic agents. The effects of 5-fluorouracil (5-FU), doxorubicin and paclitaxel on FDG and FLT uptake were measured in MDA MB231 human breast cancer cells in relation to cell cycle distribution, expression and enzyme activity of TK-1. At IC(50) concentrations, 5-FU resulted in accumulation in the G1 phase, but doxorubicin and paclitaxel induced a G2/M accumulation. Compared with untreated cells, 5-FU and doxorubicin increased TK-1 levels by >300. At 72 h, 5-FU decreased FDG uptake by 50% and FLT uptake by 54%, whereas doxorubicin increased FDG and FLT uptake by 71 and 173%, respectively. Paclitaxel increased FDG uptake with >100% after 48 h, whereas FLT uptake hardly changed. In conclusion, various chemotherapeutic agents, commonly used in the treatment of breast cancer, have different effects on the time course of uptake of both FDG and FLT in vitro. This might have implications for interpretation of clinical findings.British Journal of Cancer advance online publication, 29 July 2008; doi:10.1038/sj.bjc.6604523 www.bjcancer.com.



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