Fw: Man Dies After Lung Removal, Wrong Cancer Diagnosis

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From: Search for mesothelioma diagnosis <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Saturday, June 7, 2008 2:01:42 AM
Subject: Man Dies After Lung Removal, Wrong Cancer Diagnosis

A 61-year-old man died after doctors allegedly wrongly diagnosed him with lung cancer and removed a healthy lung in an attempt to help him live longer, the Daily Mail reported on Wednesday.

Thu, 05 Jun 2008 16:06:02 GMT

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Source: http://www.foxnews.com/story/0,2933,363469,00.html
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Fw: Cytomorphologic features of well-differentiated papillary mesothelioma in peritoneal effusion: A case report.

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Subject: Cytomorphologic features of well-differentiated papillary mesothelioma in peritoneal effusion: A case report.

[1]Diagn Cytopathol. 2008 Jun 4; 36(7): 512-515
Ikeda K, Suzuki T, Tate G, Mitsuya T

Well-differentiated papillary mesothelioma (WDPM), a distinct subtype of diffuse malignant mesothelioma, usually occurs in the peritoneum and is seen most commonly in women of reproductive age. Histologic features of WDPM include papillary growth and stout fibrous cores surrounded by a single layer of tumor cells. We present the case of a 73-year-old woman without subjective symptoms who showed signs of peritoneal effusion during a routine examination and for whom cytologic examination of the ascitic fluid was performed. Many spherical clusters, with a smooth external surface composed of a single layer of uniform cuboidal cells, were observed. Within each cluster, a collagenous ball showed light green Papanicolaou staining. Immunohistochemistry of surgical specimens showed tumor cells positive for calretinin, D(2)-40, and HBME-1 staining. The histologic diagnosis was WDPM. The identification of a collagenous ball within these clusters is a useful cytologic finding for the diagnosis of WDPM. WDPM should be suspected when numerous collagenous balls are present by effusion cytology and isolated cells are not. Diagn. Cytopathol. 2008;36:512-515. (c) 2008 Wiley-Liss, Inc.



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Source: http://www.hubmed.org/display.cgi?uids=18528881
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Fw: 'It was agonising watching him suffer'

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To: shell8377@yahoo.com
Sent: Saturday, June 7, 2008 2:01:42 AM
Subject: 'It was agonising watching him suffer'

In a landmark case starting this week, insurance companies are being sued for refusing to pay compensation to asbestos victims and their families.

Tue, 03 Jun 2008 06:51:37 GMT

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Source: http://news.bbc.co.uk/1/hi/health/7431979.stm
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Fw: Response of a Patient with Pleural and Peritoneal Mesothelioma after Second-Line Chemotherapy with Lipoplatin and Gemcitabine.

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Sent: Saturday, June 7, 2008 2:02:25 AM
Subject: Response of a Patient with Pleural and Peritoneal Mesothelioma after Second-Line Chemotherapy with Lipoplatin and Gemcitabine.

[1]Oncology. 2008 Jun 3; 73(5-6): 426-429
Karpathiou G, Argiana E, Koutsopoulos A, Froudarakis ME

We report the case of a 56-year-old patient with malignant pleural mesothelioma of epithelial type, who responded to second-line chemotherapy with lipoplatin plus gemcitabine. Diagnosis and staging of the disease was done by medical thoracoscopy with biopsies of the right pleura in December 2003, when he was treated with talc pleurodesis. Eighteen months later, he presented with pleural effusion of the left side and underwent first-line chemotherapy with cisplatin plus vinorelbine. After 8 cycles, the patient presented renal toxicity limiting further cisplatinum chemotherapy and disease progression with peritoneal invasion of the tumor and ascites. Treatment with lipoplatin-gemcitabine was decided on in November 2006, and the patient showed important improvement in the clinical status and peritoneal effusion. He survived for 36 weeks, with symptom-free survival of 34 weeks.



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Source: http://www.hubmed.org/display.cgi?uids=18523361
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Fw: Diagnostic usefulness and challenges in the diagnosis of mesothelioma by endoscopic ultrasound guided fine needle aspiration.

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From: HubMed - mesothelioma diagnosis <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Saturday, June 7, 2008 2:02:25 AM
Subject: Diagnostic usefulness and challenges in the diagnosis of mesothelioma by endoscopic ultrasound guided fine needle aspiration.

[1]Diagn Cytopathol. 2008 Jun 4; 36(7): 503-507
Bakdounes K, Jhala N, Jhala D

Malignant mesothelioma is a rare neoplasm. It has been noted in the literature that fine needle aspiration (FNA) is a useful tool for the diagnosis of mesothelioma. However, the differential diagnosis may require use of a battery of immunohistochemical stains. Clinico-radiologic correlation is also crucial. Real time endoscopic ultrasound (EUS) combined with FNA has been shown to be a very sensitive technique to obtain samples from different organ sites, including mediastinal lesions. The use of EUS-FNA for the diagnosis of mesothelioma, reinforces the role of a cytopathologist as a cohesive team player along with a radiologist and a clinician during on-site assessment for the proper triage of additional specimens for ancillary studies leading to a better patient management. Diagn. Cytopathol. 2008;36:503-507. (c) 2008 Wiley-Liss, Inc.



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Source: http://www.hubmed.org/display.cgi?uids=18528879
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Fw: [An autopsy case of diffuse pleural thickening presented respiratory impairment and benign asbestos pleurisy]

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Sent: Saturday, June 7, 2008 2:02:25 AM
Subject: [An autopsy case of diffuse pleural thickening presented respiratory impairment and benign asbestos pleurisy]

[1]Nihon Kokyuki Gakkai Zasshi. 2008 May; 46(5): 368-73
Morokawa N, Takayanagi N, Ubukata M, Kurashima K, Yoned K, Tsuchiy N, Miyahara Y, Yamaguchi S, Tokunaga D, Saito H, Yanagisawa T, Sugita Y, Kawabata Y

A 51-year-old man presented with back pain in 1997. He had a 30-year-history of occupational asbestos exposure. His chest CT showed bilateral pleural thickening and pleural effusion. The pleural effusion of the right thorax exhibited both elevated level of adenosine deaminase and increased numbers of lymphocytes. Antituberculous chemotherapy had no effect on the exudates. Progressive bilateral pleural thickening were found on chest CT, and pulmonary function tests showed severe restrictive ventilatory impairments since 1998. Thoracoscopic pleural biopsy was conducted in 2001 to exclude pleural malignant mesothelioma. No malignancy was found in pleural samples. After 3-year observation and excluding other causes, he was given a diagnosis of benign asbestos pleurisy. In 2005, fibrotic changes were found in both lower lung fields in chest CT. He suffered from respiratory failure with carbon dioxide retention, and died in 2006. The autopsy disclosed asbestos-related lung diseases. We suspected that diffuse pleural thickening could be a major cause of fatal respiratory impairment in this case.



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Source: http://www.hubmed.org/display.cgi?uids=18517012
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Fw: Image-guided pleural biopsy.

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Sent: Saturday, June 7, 2008 2:02:25 AM
Subject: Image-guided pleural biopsy.

[1]Curr Opin Pulm Med. 2008 Jul; 14(4): 331-6
Rahman NM, Gleeson FV

PURPOSE OF REVIEW: Pleural diseases are a common and increasing clinical problem. Establishing accurate diagnosis is an essential step in management of these patients, and approximately 40% of pleural effusions will remain undiagnosed after initial diagnostic thoracocentesis. Obtaining pleural tissue (by blind, image-guided or thoracoscopic pleural biopsy) is therefore a key procedure. Recent evidence provides important information on the relative value of each of these techniques. RECENT FINDINGS: For the diagnosis of malignant pleural disease, both thoracoscopic and image-guided biopsy have a far higher diagnostic yield than blind pleural biopsy. Cutting needle biopsies have a higher diagnostic yield in malignancy (and especially mesothelioma) compared with fine needle aspiration. The complication rate of image-guided biopsy is low. Rates of biopsy site tract invasion by mesothelioma may be lower using smaller biopsy ports, as used for image-guided pleural biopsy. SUMMARY: Blind pleural biopsy should no longer be conducted for the study of malignant pleural disease if facilities for other techniques are available. Image-guided and thoracoscopic biopsies have similarly high diagnostic rates, and are complementary techniques used in different clinical situations. Further studies assessing biopsy tract site invasion from mesothelioma with different biopsy techniques are required.



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Source: http://www.hubmed.org/display.cgi?uids=18520268
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