Fw: MESOMARK kit detects C-ERC/mesothelin, but not SMRP with C-terminus.

----- Forwarded Message ----
From: HubMed - mesothelioma <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Tuesday, March 11, 2008 10:08:51 PM
Subject: MESOMARK kit detects C-ERC/mesothelin, but not SMRP with C-terminus.

[1]Biochem Biophys Res Commun. 2008 Mar 4;
Segawa T, Hagiwara Y, Ishikawa K, Aoki N, Maeda M, Shiomi K, Hino O

ERC/mesothelin is expressed on the normal mesothelium and some cancers such as mesothelioma or ovarian carcinoma. A splicing isoform of ERC/mesothelin (known as SMRP), which has an 82-bp insertion and codes for a C-terminus with a hydrophilic, presumably soluble, tail instead of a GPI-anchoring signal, has been reported as a useful marker for the diagnosis of mesothelioma. However, the existence of SMRP has not yet been demonstrated in the serum of mesothelioma patients. To elucidate the existence of SMRP, we have established a new enzyme-linked immunosorbent assay (ELISA) system for SMRP. The ELISA study revealed that N- and C-ERC/mesothelin were detected in sera from mesothelioma patients, but not SMRP, even in these samples. This result showed that the SMRP detected with MESOMARK kit should be lack of soluble C-terminus and indistinguishable from C-ERC/mesothelin. Further study might be necessary to demonstrate the relationship between SMRP and mesothelin.



___
Source: http://www.hubmed.org/display.cgi?uids=18328258
--
 ~
Powered by [5]RssFwd, a service of [6]Blue Sky Factory, Inc

 

Health Wellness Sites

Health Wellness

Relieve Stress Anxiety Tensions

Holiday Stress

Mind Body Yoga

Mesothelioma

Mesothelioma diagnosis: What You Need To Know

Daily Recommended Relaxation

 Transcendental Meditation

 

More Links,  Links

http://www.lingwellness.com/privatestudentloans.php

http://www.lingwellness.com/mortgagerefinancing.php

http://www.lingwellness.com/transportdogcrates.php

http://www.lingwellness.com/airfilleddogbed.php

http://www.lingwellness.com/dogtransport.php

http://www.lingwellness.com/uniquedogcollars.php

http://www.lingwellness.com/airfilleddogbedyourbestfriendscomfort.php

http://www.lingwellness.com/petdogs.php

http://www.lingwellness.com/realestate.php

http://www.lingwellness.com/msbeachvacationcondos.php

http://www.lingwellness.com/margaterealestate.php

http://www.lingwellness.com/hudapprovedbuilders.php

http://www.lingwellness.com/floridadwidefense.php

http://www.lingwellness.com/bankruptcymarketing.php

http://www.lingwellness.com/bankruptcymailinglist.php

http://www.lingwellness.com/enterbankruptcyprotection.php

http://www.lingwellness.com/debtconsolidationuk2.php

http://www.debt2consolidationloan.com/

http://www.debt2consolidationloan.com/Consolidate_Debt_Loans_The_Right_Type_of_Debt_Consolidation_Loan.html

http://www.debt2consolidationloan.com/

http://www.lingwellness.com/dogcratetraining.php

http://www.lingwellness.com/populartransportdogcrates.php

http://www.lingwellness.com/puppycolic.php

http://www.debt2consolidationloan.com/School_Loan_Consolidation_Beginners_Info.html

http://www.debt2consolidationloan.com/School_Consolidation_Loans_Guide.html

http://www.debt2consolidationloan.com/College_Loan_Consolidation.html

http://www.debt2consolidationloan.com/Student_Loans.html

 

---

You rock. That's why Blockbuster's offering you one month of Blockbuster Total Access, No Cost.