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From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Thu, Sep 4, 2008 at 7:39 AM
Subject: A fusion protein containing murine vascular endothelial growth factor and tissue factor induces thrombogenesis and suppression of tumor growth in a colon carcinoma model.
To: mesothelioma77@gmail.com
[1]J Zhejiang Univ Sci B. 2008 Aug.; 9(8): 602-609
Huang FY, Li YN, Wang H, Huang YH, Lin YY, Tan GH
Induction of tumor vasculature occlusion by targeting a thrombogen to newly formed blood vessels in tumor tissues represents an intriguing approach to the eradication of primary solid tumors. In the current study, we construct and express a fusion protein containing vascular endothelial growth factor (VEGF) and tissue factor (TF) to explore whether this fusion protein has the capability of inhibiting tumor growth in a colon carcinoma model. The murine cDNA of VEGF A and TF were amplified by reverse transcriptase polymerase chain reaction (RT-PCR), and then cloned into prokaryotic expression plasmid pQE30 with a linker. The expression product recombinant VEGF-TF (rVEGF-TF) was purified and proved to have comparable enzyme activity to a commercial TF and the capability of specific binding to tumor vessels. Significant decrease of tumor growth was found in the mice administered with rVEGF-TF on Day 6 after initiated rVEGF-TF treatment (P
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Source: http://www.hubmed.org/display.cgi?uids=18763309
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From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Thu, Sep 4, 2008 at 7:39 AM
Subject: A fusion protein containing murine vascular endothelial growth factor and tissue factor induces thrombogenesis and suppression of tumor growth in a colon carcinoma model.
To: mesothelioma77@gmail.com
[1]J Zhejiang Univ Sci B. 2008 Aug.; 9(8): 602-609
Huang FY, Li YN, Wang H, Huang YH, Lin YY, Tan GH
Induction of tumor vasculature occlusion by targeting a thrombogen to newly formed blood vessels in tumor tissues represents an intriguing approach to the eradication of primary solid tumors. In the current study, we construct and express a fusion protein containing vascular endothelial growth factor (VEGF) and tissue factor (TF) to explore whether this fusion protein has the capability of inhibiting tumor growth in a colon carcinoma model. The murine cDNA of VEGF A and TF were amplified by reverse transcriptase polymerase chain reaction (RT-PCR), and then cloned into prokaryotic expression plasmid pQE30 with a linker. The expression product recombinant VEGF-TF (rVEGF-TF) was purified and proved to have comparable enzyme activity to a commercial TF and the capability of specific binding to tumor vessels. Significant decrease of tumor growth was found in the mice administered with rVEGF-TF on Day 6 after initiated rVEGF-TF treatment (P
___
Source: http://www.hubmed.org/display.cgi?uids=18763309
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