---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sat, Jun 21, 2008 at 6:02 PM
Subject: Genes controlling spread of breast cancer to lung "gang of 4".
To: mesothelioma77@gmail.com
[1]Exp Oncol. 2008 Jun; 30(2): 91-5
Eltarhouny SA, Elsawy WH, Radpour R, Hahn S, Holzgreve W, Zhong XY
Cancer-related mortality is caused in a large part by the metastasis of primary tumor. Each cancer has a particular way of spreading cancerous cells. Recently, genetic and pharmacological analysis identified the set of genes, such as epidermal growth factor receptor ligand epiregulin (EREG), cyclooxygenase-2 (COX2) and matrix metalloproteinases 1 and 2 (MMP-1 and MMP-2) that have been found to be associated with metastasis of breast cancer to lung. Inhibition of EGFR and COX2 could minimize lung metastasis of breast cancer in a clinical setting. In this review, we summarized the current knowledge on EREG, COX2, MMP-1 and MMP-2 in tumor development and metastasis.
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Source: http://www.hubmed.org/display.cgi?uids=18566569
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Powered by [5]RssFwd, a service of [6]Blue Sky Factory, Inc
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sat, Jun 21, 2008 at 6:02 PM
Subject: Genes controlling spread of breast cancer to lung "gang of 4".
To: mesothelioma77@gmail.com
[1]Exp Oncol. 2008 Jun; 30(2): 91-5
Eltarhouny SA, Elsawy WH, Radpour R, Hahn S, Holzgreve W, Zhong XY
Cancer-related mortality is caused in a large part by the metastasis of primary tumor. Each cancer has a particular way of spreading cancerous cells. Recently, genetic and pharmacological analysis identified the set of genes, such as epidermal growth factor receptor ligand epiregulin (EREG), cyclooxygenase-2 (COX2) and matrix metalloproteinases 1 and 2 (MMP-1 and MMP-2) that have been found to be associated with metastasis of breast cancer to lung. Inhibition of EGFR and COX2 could minimize lung metastasis of breast cancer in a clinical setting. In this review, we summarized the current knowledge on EREG, COX2, MMP-1 and MMP-2 in tumor development and metastasis.
___
Source: http://www.hubmed.org/display.cgi?uids=18566569
--
Powered by [5]RssFwd, a service of [6]Blue Sky Factory, Inc