From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Thu, Apr 17, 2008 at 4:36 AM
Subject: Src inhibitors in early breast cancer: a methodology, feasibility and variability study.
To: mesothelioma77@gmail.com
[1]Breast Cancer Res Treat. 2008 Apr 14;
Jones RJ, Young O, Renshaw L, Jacobs V, Fennell M, Marshall A, Green TP, Elvin P, Womack C, Clack G, Dixon JM
Early clinical trials of anticancer agents may be enriched by robust biomarkers of activity. Surrogate measures used in trials of cytotoxic agents, such as tumor size regression, may not be informative when investigating targeted agents that act principally to inhibit invasion or proliferation. This study aimed to determine the validity of invasion-related biomarkers of activity for AZD0530, a potent Src inhibitor currently in clinical development. Focal adhesion kinase (FAK) and paxillin are downstream phosphorylation substrates of Src and mediate tumor cell adhesion and invasiveness. These were therefore selected as biologically relevant markers of Src inhibition. Early breast cancer was chosen as a model as multiple samples can be collected during standard treatment and there is an intervening period in which experimental intervention can be applied. Tumor tissue was collected from diagnostic core biopsies and subsequent surgical tumor excision samples in 29 women with early breast cancer attending a single center. Protein levels were assessed quantitatively by Luminex((R)) and qualitatively by immunohistochemistry. AZD0530 inhibited tumor growth in a manner independent of dose and inhibited phosphorylation of FAK and paxillin in a dose-dependent manner in a Calu-6 xenograft model. In the clinical study, agreement of within-visit and also of between-visit measurements was high and the estimated number of patients required to detect a drug effect would be low enough to allow use of these markers as endpoints in future dose selection studies.
___
Source: http://www.hubmed.org/display.cgi?uids=18409068
--
Powered by [5]RssFwd, a service of [6]Blue Sky Factory, Inc
Financial Sites:
Your Finance: Debts And Loans Info
Private Student Loans: A Parent's Best Choice?
Consolidate Debt Loans: To Eliminate Credit Card Debts
Consolidate Debt Loans For Your School Debts
School Consolidation Loan Guide
School Loan Consolidation: Your Much Needed Information
Consolidate Debt Loans: For Better Debt Management
Debt Consolidation UK; Secured and Unsecured Debt Consolidation Explained
Best Mortgage Rates Refinancing
How Much Mortgage Can I Afford?
Connecticut Mortgage Refinancing
Arkansas Refinance Mortgage Rates
Home Loan Rates Berkeley Springs
Mortgage Loan Refinancing In Britain
UK Mortgage Payment Calculator
Mortgage Foreclosure Appraisal
Real Estate: Important Things to Remember
Regulations Preventing Foreclosure
http://www.lingwellness.com/ukmortgagepaymentcalculator.php
http://www.lingwellness.com/homeloanrateswv.php
http://www.lingwellness.com/mortgageratehistory.php
http://www.lingwellness.com/lowmortgageraterefinance.php
http://www.lingwellness.com/connecticutmortgagerefinancing.php
http://www.lingwellness.com/arkansasrefinancemortgagerates.php
http://www.lingwellness.com/homeloanratesberkeleysprings.php
http://www.lingwellness.com/bestmortgageratesrefinancing.php
http://www.lingwellness.com/howmuchmortgagecaniafford.php
http://www.lingwellness.com/mortgagerefinancing.php
http://www.lingwellness.com/realestate.php
http://www.lingwellness.com/msbeachvacationcondos.php
http://www.lingwellness.com/margaterealestate.php
http://www.lingwellness.com/hudapprovedbuilders.php
http://www.lingwellness.com/bankruptcymarketing.php
http://www.lingwellness.com/bankruptcymailinglist.php
http://www.lingwellness.com/enterbankruptcyprotection.php
http://www.lingwellness.com/debtconsolidationuk2.php
http://www.debt2consolidationloan.com/
http://www.debt2consolidationloan.com/
http://www.debt2consolidationloan.com/School_Loan_Consolidation_Beginners_Info.html
http://www.debt2consolidationloan.com/School_Consolidation_Loans_Guide.html
http://www.debt2consolidationloan.com/College_Loan_Consolidation.html
http://www.debt2consolidationloan.com/Student_Loans.html
Insurance And DWI and DUI:
Insurance Premiums and Your DUI, DWI
http://www.lingwellness.com/howmuchmortgagecaniafford.php
http://www.lingwellness.com/floridadwidefense.php
http://www.lingwellness.com/bestmortgageratesrefinancing.php
http://www.lingwellness.com/arkansasrefinancemortgagerates.php
http://www.lingwellness.com/howmuchmortgagecaniafford.php
Pet Dogs Sites
Air Filled Dog Bed: Your Best Friends Comfort
http://www.lingwellness.com/petdogs.php
http://www.lingwellness.com/transportdogcrates.php
http://www.lingwellness.com/airfilleddogbed.php
http://www.lingwellness.com/dogtransport.php
http://www.lingwellness.com/uniquedogcollars.php
http://www.lingwellness.com/airfilleddogbedyourbestfriendscomfort.php
http://www.lingwellness.com/dogcratetraining.php
http://www.lingwellness.com/populartransportdogcrates.php
http://www.lingwellness.com/puppycolic.php
http://www.lingwellness.com/bestmortgageratesrefinancing.php
http://www.lingwellness.com/arkansasrefinancemortgagerates.php
http://www.lingwellness.com/howmuchmortgagecaniafford.php
Health Sites
Relieve Stress Anxiety Tensions
Mesothelioma diagnosis: What You Need To Know
More Links, Links
http://www.lingwellness.com/bestmortgageratesrefinancing.php
http://www.lingwellness.com/arkansasrefinancemortgagerates.php
http://www.lingwellness.com/howmuchmortgagecaniafford.php
http://www.lingwellness.com/privatestudentloans.php
http://www.lingwellness.com/mortgagerefinancing.php
http://www.lingwellness.com/realestate.php
http://www.lingwellness.com/msbeachvacationcondos.php
http://www.lingwellness.com/margaterealestate.php
http://www.lingwellness.com/hudapprovedbuilders.php
http://www.lingwellness.com/bankruptcymarketing.php
http://www.lingwellness.com/bankruptcymailinglist.php
http://www.lingwellness.com/enterbankruptcyprotection.php
http://www.lingwellness.com/debtconsolidationuk2.php
http://www.debt2consolidationloan.com/
http://www.debt2consolidationloan.com/
http://www.debt2consolidationloan.com/School_Loan_Consolidation_Beginners_Info.html
http://www.debt2consolidationloan.com/School_Consolidation_Loans_Guide.html
http://www.debt2consolidationloan.com/College_Loan_Consolidation.html
http://www.debt2consolidationloan.com/Student_Loans.html